Pathology & Oncology Research

, Volume 25, Issue 1, pp 89–95 | Cite as

Long Non-Coding RNA SPRY4-IT1 Can Predict Poor Prognosis in Digestive System Malignancies: a Meta-Analysis

  • Cheng Sun
  • Yangyang Ding
  • Shimin Wang
  • Wei HuEmail author
Original Article


Recent studies have reported that long non-coding RNA SPRY4 intron transcript 1 (SPRY4-IT1) is abnormally expressed in malignant digestive tumors and associated with prognosis. But its clinical relevance is unclear. Here, we performed a meta-analysis aims to evaluate the prognostic value of SPRY4-IT1 in digestive system malignancies. We systematic search the PubMed, Web of Science, ScienceDirect and Wiley Online Library database to eligible studies. The pooled hazard ratios (HRs) with a 95% confidence interval (95% CI) were calculated to explored the association of lncRNA SPRY4-IT1 with prognosis. Five studies were eligible for analysis, a total of 518 patients were included. Meta-analysis indicated that overexpression of SPRY4-IT1 was associated with poor over survival (OS) (HR = 1.24, 95%CI:0.49–1.98; random-effects model). The clinicopathological parameters analysis further showed that increased expression level of SPRY4-IT1 was positively correlated with lymph node metastasis (HR = 1.45, 95% CI =0.88–2.02; fixed-effects model), TNM stage (HR = 1.24,95% CI = 0.78–1.70; fixed-effects model), and invasion depth (HR = 1.25,95% CI = 0.63–1.88; fixed-effects model). lncRNA SPRY4-IT1 may serve as a potential prognostic marker in malignant digestive tumors.


lncRNA SPRY4-IT1 Prognosis Metastasis Meta-analysis 



hazard ratios


confidence interval


overall survival


colorectal cancer


gastric cancer


esophageal squamous



This work was partly supported by This work was supported by the Natural Science Foundation of Anhui Province (9101051201).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that there is no conflict of interests regarding the publication of this paper.


  1. 1.
    Garzon R, Volinia S, Papaioannou D et al (2014) Expression and prognostic impact of lncRNAs in acute myeloid leukemia. Proc Natl Acad Sci U S A 111:18679–18684CrossRefGoogle Scholar
  2. 2.
    Kim SH, Lee HW, Go SI, Lee SI, Lee GW (2016) Clinical significance of the preoperative platelet count and platelet-to-lymphocyte ratio (PLT-PLR) in patients with surgically resected non-small cell lung cancer. Oncotarget 7:36198–36206Google Scholar
  3. 3.
    Chan JC, Chan DL, Diakos CI et al (2016) The lymphocyte-to-monocyte ratio is a superior predictor of overall survival in comparison to established biomarkers of resectable colorectal cancer. Ann Surg 265(3):539–546Google Scholar
  4. 4.
    Han Li C, Chen Y (2015) Small and long non-coding RNAs: novel targets in perspective cancer therapy. Curr Genomics 16:319–326CrossRefGoogle Scholar
  5. 5.
    Zarate R, Boni V, Bandres E, Garcia-Foncillas J (2012) MiRNAs and LincRNAs: could they be considered as biomarkers in colorectal cancer? Int J Mol Sci 13:840–865CrossRefGoogle Scholar
  6. 6.
    Yang Q, Zhang RW, Sui PC, He HT, Ding L (2015) Dysregulation of non-coding RNAs in gastric cancer. World J Gastroenterol 21:10956–10981CrossRefGoogle Scholar
  7. 7.
    Sugihara H, Ishimoto T, Miyake K et al (2015) Noncoding RNA expression aberration is associated with cancer progression and is a potential biomarker in esophageal squamous cell carcinoma. Int J Mol Sci 16:27824–27834CrossRefGoogle Scholar
  8. 8.
    Wong DT (2015) Salivary extracellular noncoding RNA: emerging biomarkers for molecular diagnostics. Clin Ther 37:540–551CrossRefGoogle Scholar
  9. 9.
    Cao D, Ding Q, Yu W, Gao M, Wang Y (2016) Long noncoding RNA SPRY4-IT1 promotes malignant development of colorectal cancer by targeting epithelial-mesenchymal transition. Onco Targets Ther 9:5417–5425CrossRefGoogle Scholar
  10. 10.
    Tan W, Song ZZ, Xu Q et al (2017) Up-regulated expression of spry4-it1 predicts poor prognosis in colorectal cancer. Med Sci Monit 23:309–314CrossRefGoogle Scholar
  11. 11.
    Peng W, Wu G, Fan H, Wu J, Feng J (2015) Long noncoding RNA SPRY4-IT1 predicts poor patient prognosis and promotes tumorigenesis in gastric cancer. Tumour Bio l36:6751–6758Google Scholar
  12. 12.
    Xie M, F-q N, Sun M et al (2015) Decreased long noncoding RNA SPRY4-IT1 contributing to gastric cancer cell metastasis partly via affecting epithelial-mesenchymal transition. J Transl Med 13:250CrossRefGoogle Scholar
  13. 13.
    Xie H-W, Wu Q-Q, Zhu B et al (2014) Long noncoding RNA SPRY4-IT1 is upregulated in esophageal squamous cell carcinoma and associated with poor prognosis. Tumor Biol 35:7743–7754CrossRefGoogle Scholar
  14. 14.
    Ferlay J, Soerjomataram I, Dikshit R et al (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:E359–E386CrossRefGoogle Scholar
  15. 15.
    George J, Patel T (2015) Noncoding RNA as therapeutic targets for hepatocellular carcinoma. Semin Liver Dis 35:63–74CrossRefGoogle Scholar
  16. 16.
    Jin K, Luo G, Xiao Z et al (2015) Noncoding RNAs as potential biomarkers to predict the outcome in pancreatic cancer. Drug Des Dev Ther 9:1247–1255CrossRefGoogle Scholar
  17. 17.
    Khaitan D, Dinger ME, Mazar J et al (2011) The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion. Cancer Res 71:3852–3862CrossRefGoogle Scholar
  18. 18.
    Sun M, Liu XH, Lu KH et al (2014) EZH2-mediated epigenetic suppression of long noncoding RNA SPRY4-IT1 promotes NSCLC cell proliferation and metastasis by affecting the epithelial-mesenchymal transition. Cell Death Dis 5:e1298CrossRefGoogle Scholar
  19. 19.
    Shi Y, Li J, Liu Y et al (2015) The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression. Mol Cancer 14:51CrossRefGoogle Scholar

Copyright information

© Arányi Lajos Foundation 2017

Authors and Affiliations

  1. 1.Department of PharmacologyThe Second Hospital of Anhui Medical UniversityHefeiPeople’s Republic of China
  2. 2.Department of Hematology/Hematological LabThe Second Hospital of Anhui Medical UniversityHefeiPeople’s Republic of China

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