Pathology & Oncology Research

, Volume 24, Issue 1, pp 167–170 | Cite as

Is Regression after Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer Different in Sentinel and Non-sentinel Nodes?

  • Gábor Cserni
  • Tamás Zombori
  • Xavier Andreu
  • Simonetta Bianchi
  • Peter Regitnig
  • Isabel Amendoeira
  • Davide Balmativola
  • Anikó Kovács
  • Alicia Cordoba
  • Angelika Reiner
  • Janina Kulka
  • Handan Kaya
  • Inta Liepniece-Karele
  • Cecily Quinn
  • Bence Kővári
Short Communication

Abstract

Tumor draining sentinel lymph nodes (SLNs) are the sites of selective changes as compared to non-SLNs. They show features of tumor-reactive lymphadenopathy, including increased total number of functional blood vessels, but a relative immunosuppressed status has also been described in them. We explored the hypothesis of a selective regression or non-regression in SLNs versus non-SLNs in 142 patients with 110 estrogen receptor-positive and 32 estrogen receptor-negative tumors undergoing both SLN biopsy and axillary lymph node dissection after neoadjuvant therapy by assessing the tumoral (metastatic) and regression statuses of SLNs and non-SLNs separately. Of the 89 cases with signs of nodal regression, 22 cases (25%) were in favor of a selective non-regression in SLNs, 18 cases (20%) were supportive of a selective and more pronounced regression in the SLNs and the remaining showed equal degrees of regression or non-regression in SLNs and non-SLNs. The results indicate that there is no obvious difference in the degree of regressive histological changes shown by SLNs and NSLNs. Therefore, this phenomenon may not be a major contributor to the higher false negative rate of SLN biopsy after neoadjuvant treatment.

Keywords

Sentinel lymph node Non-sentinel lymph node Breast cancer Neoadjuvant therapy Selective regression 

Notes

Acknowledgements

The study was supported by the National Research, Development and Innovation Office grant GINOP-2.3.2-15-2016-00020. The content of the communications has not been influenced by this support.

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Copyright information

© Arányi Lajos Foundation 2017

Authors and Affiliations

  • Gábor Cserni
    • 1
    • 2
  • Tamás Zombori
    • 2
  • Xavier Andreu
    • 3
  • Simonetta Bianchi
    • 4
  • Peter Regitnig
    • 5
  • Isabel Amendoeira
    • 6
  • Davide Balmativola
    • 7
  • Anikó Kovács
    • 8
  • Alicia Cordoba
    • 9
  • Angelika Reiner
    • 10
  • Janina Kulka
    • 11
  • Handan Kaya
    • 12
  • Inta Liepniece-Karele
    • 13
  • Cecily Quinn
    • 14
  • Bence Kővári
    • 2
  1. 1.Department of PathologyBács-Kiskun County Teaching HospitalKecskemétHungary
  2. 2.Department of PathologyUniversity of SzegedSzegedHungary
  3. 3.Department of PathologyCorporació Sanitària Parc Taulí, University Autònoma BarcelonaSabadellSpain
  4. 4.Division of Pathological Anatomy, Department of Surgery and Translational MedicineAOU CareggiFlorenceItaly
  5. 5.Institute of PathologyMedical University of GrazGrazAustria
  6. 6.Laboratório de Anatomia PatológicaCentro Hospitalar de São João e IPATIMUPPortoPortugal
  7. 7.Candiolo Cancer Institute - Fondazione del Piemonte per l’Oncologia (FPO), IRCCSCandiolo, ToItaly
  8. 8.Department of Clinical Pathology and GeneticsSahlgrenska University HospitalGothenburgSweden
  9. 9.Department of PathologyComplejo Hospitalario de NavarraPamplonaSpain
  10. 10.Pathologisch-Bakteriologisches Institut, Donauspital am SMZOViennaAustria
  11. 11.2nd Department of PathologySemmelweis University BudapestBudapestHungary
  12. 12.Department of PathologyMarmara University, School of MedicineIstanbulTurkey
  13. 13.Pathology Centre, Riga East Clinical University HospitalRigaLatvia
  14. 14.School of Medicine, University College DublinSt. Vincent’s University HospitalDublin 4Ireland

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