Pathology & Oncology Research

, Volume 22, Issue 2, pp 245–252 | Cite as

Filamin A: Insights into its Exact Role in Cancers

  • Qian-Qian Shao
  • Tai-Ping Zhang
  • Wen-Jing Zhao
  • Zi-Wen Liu
  • Lei You
  • Li Zhou
  • Jun-Chao Guo
  • Yu-Pei Zhao
Review

Abstract

Filamin A (FlnA) is a well-known actin cross-linking protein. It serves as a scaffold for over 90 binding partners and involves in multiple cell functions, of which cell migration and adhesion is especially critical. Recently, its role in the cell has come under scrutiny for FlnA’s involvement in cancer development. Originally revealed as a cancer-promoting protein, FlnA actually plays a dual role in cancers. When localized to the cytoplasm, FlnA has a tumor-promoting effect by interacting with signaling molecules. While once localized to the nucleus, it may act to suppress tumor growth and inhibit metastasis by interacting with transcription factors. Thus drugs that can cause FlnA to transpose from cytoplasm to nucleus could be a promising treatment for cancers. Study to this end is on the way in prostate cancer and the results are encouraging. FlnA has been studied in large categories of cancers, such as prostate cancer, breast cancer, melanoma, lung cancer, etc. However, most studies did not evaluate the differences that arise from the localization of the protein, which was a great pity! What’s more, although FlnA’s is undoubtedly important in cancer invasion and metastasis, both preclinical and clinical researches are very rare in some highly metastatic cancers, such as pancreatic cancer. In this mini-review, we give a comprehensive summary of FlnA’ s expression in cancers. Where available, we also indicate the correlation of FlnA with cancer stages and patient prognosis, and clarify its localization (nucleus/cytoplasm) and its dual role (promote/suppress) in different cancers.

Keywords

Filamin A Cancer metastasis Localization Nucleus Cytoplasm 

Abbreviations

FlnA

Filamin A

ABD

Actin-binding domain

MK

Megakaryocyte

PMSA

Prostate-specific membrane antigen

hAR

Human androgen receptor

ADT

Androgen deprivation therapy

CRPC

Castration-resistant prostate cancer

GCP

Genistein-combined-polysaccharide

RCC

Renal cell carcinoma

PrP

Prion protein

EGFR

Epidermal growth factor receptor

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Copyright information

© Arányi Lajos Foundation 2015

Authors and Affiliations

  • Qian-Qian Shao
    • 1
  • Tai-Ping Zhang
    • 1
  • Wen-Jing Zhao
    • 1
  • Zi-Wen Liu
    • 1
  • Lei You
    • 1
  • Li Zhou
    • 1
  • Jun-Chao Guo
    • 1
  • Yu-Pei Zhao
    • 1
  1. 1.Department of General Surgery, Peking Union Medical College HospitalChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina

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