Pathology & Oncology Research

, Volume 21, Issue 1, pp 83–95 | Cite as

Association of Serum Levels of CEA, CA199, CA125, CYFRA21-1 and CA72-4 and Disease Characteristics in Colorectal Cancer

  • Wa Zhong
  • Zhong Yu
  • Jun Zhan
  • Tao Yu
  • Ying Lin
  • Zhong-Sheng Xia
  • Yu-Hong Yuan
  • Qi-Kui Chen


Identifying predictive biomarkers for colorectal cancer would facilitate diagnosis and treatment of the disease. This study aimed to investigate the association of the serological biomarkers CEA, CA19–9, CA125, CYFRA21–1 and CA72–4 with patient characteristics and disease outcomes in colorectal cancer. Patients (N = 373) with colorectal cancer were evaluated for the association of CEA, CA19–9, CA125, CYFRA21–1, and CA72–4 pre and post-surgery and at disease recurrence with demographics, disease characteristics including pathological types, degree of differentiation, invasion depth, abdominal lymph node metastasis, TMN stage, Dukes stage, location of cancer and metastasis, and disease outcomes. It was more common for a patient to express these markers prior to surgery and at disease recurrence than following surgery. Overall, the serum levels of CEA, CA19–9, CA125, CYFRA21–1, and CA72–4 were not associated with age, gender, pathological type and location of cancer (all P-values >0.05), but were associated with the poor tumor differentiation, higher tumor invasion, greater degree of abdominal lymph node metastasis, and higher TNM and Duke stage tumors (all P-values < 0.01). CEA expression was associated with older ages (median age 65 years). Multivariate analysis indicated that CEA was correlated with overall survival and none of the markers correlated with disease recurrence. The expression of CEA, CA19–9, CA125, CYFRA21–1, and CA72–4 was associated with specific disease characteristics which tended to indicated more advanced disease and disease recurrence consistent with these biomarkers being useful for detecting colorectal cancer.


Colorectal cancer Cancer marker TNM stage Duke stage Overall survival 



This study was funded by the Science and technology and social development project of Guangdong Province (No.2012B031800030).

Conflict of Interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Arányi Lajos Foundation 2014

Authors and Affiliations

  • Wa Zhong
    • 1
  • Zhong Yu
    • 1
  • Jun Zhan
    • 1
  • Tao Yu
    • 1
  • Ying Lin
    • 1
  • Zhong-Sheng Xia
    • 1
  • Yu-Hong Yuan
    • 1
  • Qi-Kui Chen
    • 1
  1. 1.Department of Gastroenterology, Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouPeople’s Republic of China

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