Pathology & Oncology Research

, Volume 20, Issue 4, pp 879–883

The Predictive Value for Pulmonary Infection by Area Over the Neutrophil Curve (D-index) in Patients Who Underwent Reduced Intensity Hematopoietic Stem Cell Transplantation

  • Jun Aoki
  • Masaharu Tsubokura
  • Kazuhiko Kakihana
  • Gaku Oshikawa
  • Takeshi Kobayashi
  • Noriko Doki
  • Hisashi Sakamaki
  • Kazuteru Ohashi
Research

DOI: 10.1007/s12253-014-9768-8

Cite this article as:
Aoki, J., Tsubokura, M., Kakihana, K. et al. Pathol. Oncol. Res. (2014) 20: 879. doi:10.1007/s12253-014-9768-8
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Abstract

We evaluated the predictive value of the D-index for pulmonary infection in the early phase of reduced intensity stem cell transplantation (RIST). Out of 68 patients, ten patients developed a pulmonary infection within 100 days after RIST. Both the D-index and the cD-index were higher in the patients with pulmonary infection than in the control group (P = 0.009, P = 0.042, respectively). The best sensitivity and specificity, calculated with receiver operating characteristic curves, showed that the D-index was superior to the duration of neutropenia in predicting pulmonary infection. We also evaluated the utility of a cumulative D-index until 21 days after RIST (D21-index). The D21-index was higher in the patients with pulmonary infection (P = 0.047). The cutoff value of the D21-index was lower than that of the D-index (8650 vs. 11000) with comparable sensitivity and specificity. Our results demonstrate that the D21-index, as well as the D-index, are useful tools for the prediction of pulmonary infection in RIST.

Keywords

D-index cD-index D21-index Pulmonary infection Reduced intensity conditioning regimen 

Copyright information

© Arányi Lajos Foundation 2014

Authors and Affiliations

  • Jun Aoki
    • 1
  • Masaharu Tsubokura
    • 1
  • Kazuhiko Kakihana
    • 1
  • Gaku Oshikawa
    • 1
  • Takeshi Kobayashi
    • 1
  • Noriko Doki
    • 1
  • Hisashi Sakamaki
    • 1
  • Kazuteru Ohashi
    • 1
  1. 1.Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases CenterKomagome HospitalBunkyo-kuJapan

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