Pathology & Oncology Research

, Volume 19, Issue 4, pp 731–737

Collagen Triple Helix Repeat Containing-1 (CTHRC1) Expression in Invasive Ductal Carcinoma of the Breast: The Impact on Prognosis and Correlation to Clinicopathologic Features

  • Joo Heon Kim
  • Tae-Hwa Baek
  • Hyun Sun Yim
  • Kyo Hyun Kim
  • Seong-Hoo Jeong
  • Ho Bum Kang
  • Sang-seok Oh
  • Hee Gu Lee
  • Jae Wha Kim
  • Kwang Dong Kim
Research

Abstract

CTHRC1 has been known as a regulator of collagen expression and cell migration. The aim of this research was to clarify the clinicopathologic significance of CTHRC1 expression in human breast cancer. 22 cases of breast cancer tissues, randomly selected from clinically diagnosed patients, showed a significant increase of CTHRC1 mRNA expression compared to the normal tissue from the same patients using RT-PCR and real-time PCR. Additionally we investigated breast cancers from 189 patients by immunohistochemistry (IHC). A high level of CTHRC1 expression was observed in 111 (58.7 %) out of 189 breast cancer patients and the expression was significantly correlated with histologic grade (P = 0.026), nodal status (P < 0.001), and TNM pathologic stage (P = 0.002). High CTHRC1 expression was associated with a shorter recurrence free survival (P = 0.008). Taken together, the results showed that CTHRC1 over-expression was significantly associated with clinicopathological factors of poor prognosis in invasive ductal carcinoma. CTHRC1 could be used as a supplementary prognostic biomarker and a potential therapeutic target in breast cancer.

Keywords

CTHRC1 Immunohistochemistry Metastasis Breast cancer 

Copyright information

© Arányi Lajos Foundation 2013

Authors and Affiliations

  • Joo Heon Kim
    • 1
  • Tae-Hwa Baek
    • 1
  • Hyun Sun Yim
    • 1
  • Kyo Hyun Kim
    • 2
  • Seong-Hoo Jeong
    • 3
  • Ho Bum Kang
    • 4
  • Sang-seok Oh
    • 5
  • Hee Gu Lee
    • 4
  • Jae Wha Kim
    • 4
  • Kwang Dong Kim
    • 5
  1. 1.Department of PathologyEulji University School of MedicineDaejeonRepublic of Korea
  2. 2.Preventive MedicineEulji University School of MedicineDaejeonRepublic of Korea
  3. 3.Department of Surgery, Medical SchoolChonbuk National UniversityChonjuRepublic of Korea
  4. 4.Medical Genomics Research CenterKorea Research Institute of Bioscience and BiotechnologyDaejeonRepublic of Korea
  5. 5.Division of Applied Life Science (BK21), PMBBRCGyeongsang National University, 501 Jinju-daeroJinjuRepublic of Korea

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