Pathology & Oncology Research

, Volume 19, Issue 3, pp 447–450 | Cite as

Prevention of Needle-Tract Seeding by Two-Step Freezing after Lung Cancer Biopsy

  • Feng Mu
  • Shu-Peng Liu
  • Xu-Long Zhou
  • Ji-Bing ChenEmail author
  • Hai-Bo LiEmail author
  • Jian-Sheng Zuo
  • Ke-Cheng Xu


Fine-needle aspiration biopsy is a method to detect malignancy for undetermined pulmonary nodules, but has the potential to spread malignant cells from the tumor to the pleural cavity or chest wall. We developed a two-step freezing method to avoid needle-tract seeding, by use of percutaneous cryoablation after biopsy but before the biopsy needle was removed. A man aged 72 years was admitted because of a large mass in right upper lobe. After biopsy, the patient underwent surgery. Pathological assessment of the resected tumor showed that tissue around the biopsy probe and cryoprobe had been killed before needle withdrawal.


Biopsy Percutaneous cryoablation Lung cancer Pathology 



This work was supported by a grant from the Science and Technology Project of Medical Instruction (No: 2010-T-25), Guangzhou, China.

Conflicts of interest

We declare that we have no conflicts of interest.


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Copyright information

© Arányi Lajos Foundation 2013

Authors and Affiliations

  1. 1.Guangzhou Fuda HospitalInstitutes of Biomedicine and Health, Chinese Academy of ScienceGuangzhouChina

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