Pathology & Oncology Research

, Volume 18, Issue 1, pp 43–48 | Cite as

Fc-Gamma-Receptor IIIa Polymorphism and Gene Expression Profile Do Not Predict the Prognosis in Diffuse Large B-cell Lymphoma Treated with R-CHOP Protocol

  • László VáróczyEmail author
  • Erika Zilahi
  • Ágnes Gyetvai
  • Béla Kajtár
  • Lajos Gergely
  • Sándor Sipka
  • Árpád Illés


The addition of rituximab to conventional chemotherapy has significantly improved the treatment outcome in diffuse large B-cell lymphoma. However, differences in treatment response and survival data can be observed independently from the International Prognostic Index scores. The current study evaluated the impact of Fc-gamma-receptor IIIa polymorphism and gene expression profile on the response of DLBCL patients to R-CHOP therapy as well as on their survival results. Fifty-one patients were involved, thirty-two females, nineteen males, their median age was 53.1 years. The FCGR3A polymorphism at the 158. amino acid position determined with PCR method showed the following results: VV: 12 cases (23.5%), VF: 29 cases (56.8%) and FF: 10 cases (19.6%), respectively. There was no significant difference between the treatment responses of the three groups. The event-free survival data were less favorable in the F-allele carriers than in V/V homozygous patients, but without any significancy, and the overall survival curves were almost the same. As for the gene expression profile, 20 patients’ biopsy specimens showed germinal center and 31 showed non-germinal center characteristics. Treatment results did not differ from each other in the two groups. Both the event-free and the overall survival data were more favorable in the GC group, however the differences were not significant. Our results contest the predictive value of Fc-gamma-receptor IIIa polymorphism and gene expression profile in diffuse large B-cell lymphoma.


Diffuse large B-cell lymphoma Rituximab Fc-gamma-receptor IIIa polymorphism Gene expression profile Treatment response Survival 



Activated B-cell


Antibody dependent cellular cytotoxicity


Base pair


Cluster designation


Diffuse large B-cell lymphoma


Desoxy ribonucleic acid


Event-free survival




Fc-gamma-receptor IIIa


Germinal center


International prognostic index


Messenger ribonucleic acid


Natural killer


Overall survival


Polymerase chain reactiom


Rituximab, cyclophosphamide, H-daunorubicine, oncovin, prednisolone





This work was supported by the MECENATURA grant of the University of Debrecen.


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Copyright information

© Arányi Lajos Foundation 2011

Authors and Affiliations

  • László Váróczy
    • 1
    Email author
  • Erika Zilahi
    • 2
  • Ágnes Gyetvai
    • 2
  • Béla Kajtár
    • 3
  • Lajos Gergely
    • 1
  • Sándor Sipka
    • 2
  • Árpád Illés
    • 1
  1. 1.3rd Department of Medicine, Institute for Medicine, Medical and Health Science CenterUniversity of DebrecenDebrecenHungary
  2. 2.Regional Laboratory for Immunology, Medical and Health Science CenterUniversity of DebrecenDebrecenHungary
  3. 3.Department of PathologyUniversity of PécsPécsHungary

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