Pathology & Oncology Research

, 17:463 | Cite as

Cellular and Molecular Mechanisms in the Two Major Forms of Inflammatory Bowel Disease

  • Laszlo Bene
  • Andras FalusEmail author
  • Noemi Baffy
  • Andras Kristof Fulop


The factors involved in the pathogenesis of Crohn’s disease and ulcerative colitis, the two major types of inflammatory bowel disease (IBD) are summarized. Intestinal antigens composed of bacterial flora along with antigen presentation and impaired mucosal barrier have an important role in the initiation of IBD. The bacterial community may be modified by the use of antibiotics and probiotics. The dentritic cells recognize the antigens by cell surface Toll like receptor and the cytoplasmic CARD/NOD system. The balance between Th1/Th2/Th17 cell populations being the source of a variety of cytokines regulates the inflammatory mechanisms and the clearance of microbes. The intracellular killing and digestion, including autophagy, are important in the protection against microbes and their toxins. The homing process determines the location and distribution of the immune cells along the gut. All these players are potential targets of pharmacological manipulation of disease status.


Crohn’s disease Inflammatory bowl disease Intestinal tract Ulcerative colitis 



antigen presenting cell


autophagy-related protein 16–1


caspase recruitment domain-containing protein


Chron’s disease


cluster of differentiation


crohn’s disease activity index




dendritic cell


dextran sulphate sodium


Epstein-Barr virus induced gene


gut associated lymphoid tissue


granulocyte colony stimulating factor


inflammatory bowel disease


intercellular adhesion molecule


intestinal epithelial cells








immunity-related GTPase family M


keratinocyte growth factor


Ras-1 kinase suppressor


lymphocyte function-associated antigen




major histocompatibility complex


matrix metalloprotease


nicotinamide adenine dinucleotide phosphate


neutrophil cytosol factor


nuclear factor


natural killer T cell


NOD type receptor


nucleotide-binding oligomerization domain protein


pathogen associated molecular pattern


proteinase activated receptor


peroxisome proliferator activated receptor


pattern recognition receptor


recombination-activating gene


rat sarcoma oncogene


severe combined immunodeficiency


vertebrate homologue of Mad (Mothers Against Decapentaplegic) protein


suppressor of cytokine signaling


signal transducers and activators of transcription


transforming growth factor


T helper


toll-like receptor


trinitrobenzoic acid


tumor necrosis factor


TNF receptor


T cell receptor


ulcerative colitis


vascular cell adhesion molecule


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Copyright information

© Arányi Lajos Foundation 2011

Authors and Affiliations

  • Laszlo Bene
    • 1
  • Andras Falus
    • 2
    • 3
    Email author
  • Noemi Baffy
    • 2
  • Andras Kristof Fulop
    • 2
  1. 1.Department of Internal MedicinePeterfy HospitalBudapestHungary
  2. 2.Department of Genetics, Cell and ImmunobiologySemmelweis UniversityBudapestHungary
  3. 3.Research Group for Inflammation Biology and Immunogenomics of Hungarian Academy of SciencesSemmelweis UniversityBudapestHungary

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