Pathology & Oncology Research

, Volume 17, Issue 2, pp 415–420

Well-Differentiated Liposarcoma of the Oesophagus: Clinicopathological, Immunohistochemical and Array CGH Analysis

  • Jae Kyung Myung
  • Ji Bong Jeong
  • Daehee Han
  • Chi Sung Song
  • Hyeon Jong Moon
  • Young A. Kim
  • Ji Eun Kim
  • Sun-ju Byun
  • Woo Ho Kim
  • Mee Soo Chang
Case Report

Abstract

Liposarcoma develops extremely rarely in the oesophagus. Microscopically, it exhibits subtle atypia of H&E-stained features. Accordingly, immunohistochemical features and chromosomal alterations are used for its confirmatory diagnosis. However, cytogenetic analysis has not been performed for oesophageal liposarcoma. We studied chromosomal alterations using array comparative genomic hybridization (CGH), as well as endoscopic, radiological, H&E-stained and immunohistochemical features in the oesophageal well-differentiated liposarcoma of a 67-year-old man. Array CGH analysis revealed the presence of high-level amplifications at chromosomal locations 1p12–1q21.2, 12q13.2–12q15 and 12q21.33–12q23.1. At least 29 genes were highly amplified (log2 ratio >2), among which CDK4 and MDM2 were the most highly amplified (log2 ratio >4) and were accepted as major target genes. Moreover, the amplification of AMDHD1, HAL and LTA4H (log2 ratio = 3.153) was a novel finding. This case suggests the presence of a characteristic profile of gene amplification in well-differentiated liposarcoma of the oesophagus. The amplified genes may be of pathogenic importance for primary oesophageal well-differentiated liposarcoma.

Keywords

Oesophagus Well-differentiated liposarcoma Array comparative genomic hybridization Chromosome CDK4 MDM2 

References

  1. 1.
    Mansour KA, Fritz RC, Jacobs DM, Vellios F (1983) Pedunculated liposarcoma of the esophagus: a first case report. J Thorac Cardiovasc Surg 86:447–450PubMedGoogle Scholar
  2. 2.
    Boggi U, Viacava P, Naccarato AG, Giulianotti PC, di Candio G, Battolla L, Mosca F (1997) Giant pedunculated liposarcomas of the esophagus: literature review and case report. Hepatogastroenterology 44:398–407PubMedGoogle Scholar
  3. 3.
    Garcia M, Buitrago E, Bejarano PA, Casillas J (2004) Large esophageal liposarcoma: a case report and review of the literature. Arch Pathol Lab Med 128:922–925PubMedGoogle Scholar
  4. 4.
    Yang B, Shi PZ, Li X, Xu RJ (2006) Well-differentiated liposarcoma of esophagus. Chin Med J Engl 119:438–440PubMedGoogle Scholar
  5. 5.
    Will U, Lorenz P, Urban H, Meyer F (2007) Curative endoscopic resection of huge pedunculated esophageal liposarcoma. Endoscopy 39:E15–E16PubMedCrossRefGoogle Scholar
  6. 6.
    Xu S, Xu Z, Hou Y, Tan Y (2008) Primary pedunculated giant esophageal liposarcoma: case report. Dysphagia 23:327–330PubMedCrossRefGoogle Scholar
  7. 7.
    Fletcher CDM, Unni K, Mertens F (2000) World health organization classification of tumours. Pathology and genetics. Tumours of soft tissue and bone. IARC, Lyon, pp 35–46Google Scholar
  8. 8.
    Dei Tos AP, Doglioni C, Piccinin S et al (2000) Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours. J Pathol 190:531–536PubMedCrossRefGoogle Scholar
  9. 9.
    Pedeutour F, Forus A, Coindre JM et al (1999) Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors. Genes Chromosom Cancer 24:30–41PubMedCrossRefGoogle Scholar
  10. 10.
    Persson F, Olofsson A, Sjögren H, Chebbo N, Nilsson B, Stenman G, Aman P (2008) Characterization of the 12q amplicons by high-resolution, oligonucleotide array CGH and expression analyses of a novel liposarcoma cell line. Cancer Lett 260:37–47PubMedCrossRefGoogle Scholar
  11. 11.
    Fritz B, Schubert F, Wrobel G et al (2002) Microarray-based copy number and expression profiling in dedifferentiated and pleomorphic liposarcoma. Cancer Res 62:2993–2998PubMedGoogle Scholar
  12. 12.
    Assie G, Guillaud-Bataille M, Ragazzon B, Bertagna X, Bertherat J, Clauser E (2010) The pathophysiology, diagnosis and prognosis of adrenocortical tumors revisited by transcriptome analyses. Trends Endocrinol Metab 21:325–334PubMedCrossRefGoogle Scholar
  13. 13.
    Aleman G, Ortíz V, Langley E, Tovar AR, Torres N (2005) Regulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cells. Am J Physiol Endocrinol Metab 289:E172–179PubMedCrossRefGoogle Scholar
  14. 14.
    Via M, De Giacomo A, Corvol H et al (2010) Role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos. Clin Exp Allergy 40:482–589Google Scholar
  15. 15.
    Ishii K, Zaitsu M, Yonemitsu N, Kan Y, Hamasaki Y, Matsuo M (2009) 5-5-lipoxygenase pathway promotes cell proliferation in human glioma cell lines. Clin Neuropathol 28:445–452PubMedGoogle Scholar
  16. 16.
    Kubbutat MH, Jones SN, Vousden KH (1997) Regulation of p53 stability by Mdm2. Nature 387:299–303PubMedCrossRefGoogle Scholar
  17. 17.
    Shangary S, Wang S (2008) Targeting the MDM2-p53 interaction for cancer therapy. Clin Cancer Res 14:5318–5324PubMedCrossRefGoogle Scholar
  18. 18.
    Sherr CJ (1996) Cancer cell cycles. Science 274:1672–1677PubMedCrossRefGoogle Scholar

Copyright information

© Arányi Lajos Foundation 2010

Authors and Affiliations

  • Jae Kyung Myung
    • 1
    • 2
  • Ji Bong Jeong
    • 3
  • Daehee Han
    • 4
  • Chi Sung Song
    • 5
  • Hyeon Jong Moon
    • 6
  • Young A. Kim
    • 1
    • 2
  • Ji Eun Kim
    • 1
    • 2
  • Sun-ju Byun
    • 1
    • 2
  • Woo Ho Kim
    • 2
  • Mee Soo Chang
    • 1
    • 2
  1. 1.Department of Pathology, Seoul National University Boramae HospitalSeoul National University College of MedicineSeoulKorea
  2. 2.Department of PathologySeoul National University College of MedicineSeoulKorea
  3. 3.Department of Internal MedicineSeoul National University Boramae HospitalSeoulKorea
  4. 4.Department of RadiologyCatholic University Seoul St. Mary’s HospitalSeoulKorea
  5. 5.Department of RadiologySeoul National University Boramae HospitalSeoulKorea
  6. 6.Department of Thoracic SurgerySeoul National University Boramae HospitalSeoulKorea

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