Pathology & Oncology Research

, Volume 16, Issue 3, pp 337–344

Serum Vascular Endothelial Growth Factors A, C and D in Human Breast Tumors

  • Iwona Gisterek
  • Rafal Matkowski
  • Aleksandra Lacko
  • Pawel Sedlaczek
  • Krzysztof Szewczyk
  • Przemyslaw Biecek
  • Agnieszka Halon
  • Urszula Staszek
  • Jolanta Szelachowska
  • Marek Pudelko
  • Marek Bebenek
  • Antonina Harlozinska-Szmyrka
  • Jan Kornafel
Article

DOI: 10.1007/s12253-009-9211-8

Cite this article as:
Gisterek, I., Matkowski, R., Lacko, A. et al. Pathol. Oncol. Res. (2010) 16: 337. doi:10.1007/s12253-009-9211-8

Abstract

Available evidence suggests that vascular endothelial growth factor (VEGF) a potent regulator of vasculogenesis and tumor angiogenesis may be a predictor of recurrence in breast cancer patients. We sought to determine whether VEGF serum levels (VEGF-A, VEGF-C and VEGF-D) in 377 patients with malignant and benign breast tumors differ and whether there is association between vascular growth factors, clinicopathologic features and prognosis. There was no significant difference in investigated circulating angiogenic markers between patients with malignant and non malignant lesions. We found strong correlation between VEGF-A and VEGF-D and between VEGF- C and VEGF-D. Besides serum VEGF-D levels and estrogen receptor (ER) expressions no other correlations between VEGF and clinicopathologic variables were observed. However, elevated VEGF-A and VEGF-C concentrations were associated with increased number of erythrocytes, leukocytes and platelets. In Cox model values of angiogenic serum markers and recognized prognostic markers in breast cancer, VEGF-C turned out as independent prognostic factor. Our study is the first analysis showing correlation between serum concentrations of three angiogenic factors: VEGF-A, VEGF-C, VEGF-D. Associations between angiogenic cytokines and number of blood cells may be due to release of VEGF from platelets and leucocytes. Prognostic role of VEGF is still uncertain, though VEGF-C has a potential to serve as a prognostic marker.

Keywords

Vascular endothelial growth factor-A Vascular endothelial growth factor-C Vascular endothelial growth factor-D Serum assay Breast cancer 

Copyright information

© Arányi Lajos Foundation 2009

Authors and Affiliations

  • Iwona Gisterek
    • 1
  • Rafal Matkowski
    • 1
  • Aleksandra Lacko
    • 1
  • Pawel Sedlaczek
    • 2
  • Krzysztof Szewczyk
    • 1
  • Przemyslaw Biecek
    • 4
  • Agnieszka Halon
    • 5
  • Urszula Staszek
    • 1
  • Jolanta Szelachowska
    • 1
  • Marek Pudelko
    • 3
  • Marek Bebenek
    • 3
  • Antonina Harlozinska-Szmyrka
    • 2
  • Jan Kornafel
    • 1
  1. 1.Department of OncologyWroclaw Medical UniversityWroclawPoland
  2. 2.Department of Clinical ImmunologyWroclaw Medical UniversityWroclawPoland
  3. 3.Department of Oncological SurgeryLower Silesian Oncology CenterWroclawPoland
  4. 4.Faculty of Mathematics, Informatics, and MechanicsUniversity of WarsawWarsawPoland
  5. 5.Department of PathomorphologyWroclaw Medical UniversityWroclawPoland

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