Pathology & Oncology Research

, 15:473 | Cite as

Expression of EphA2 and E-cadherin in Gastric Cancer: Correlated with Tumor Progression and Lymphogenous Metastasis

  • Weijie Yuan
  • Zhikang Chen
  • Shaobin Wu
  • Jie Ge
  • Shi Chang
  • Xianwei Wang
  • Jingxiang Chen
  • Zihua Chen
Original Paper


In this study, gastric cancer progression was correlated with the over-expression of erythropoietin-producing hepatocellular (Eph)A2 receptor and down-expression of epithelial cadherin (E-cadherin). Immunohistochemistry of EphA2 and E-cadherin were performed on these tumor samples from 165 primary lesions of gastric cancer. The results showed that expression of EphA2 was obviously increased in gastric cancer tissues (P < 0.01), which was positively correlated with the depth of cancer invasion, tumor-node-metastasis (TNM) stage and lymph node metastasis (P < 0.05). Meanwhile, the expression of E-cadherin was significantly reduced (P < 0.01), which was negatively correlated with the depth of cancer invasion, grade of tumor differentiation, TNM stage and lymph node metastasis (P < 0.05). The correlation between EphA2 and E-cadherin expression was negative (r = −0.198, P = 0.011). In conclusion, either the over-expression of EphA2 or the down-expression of E-cadherin is correlated with cancer progression and lymphogenous metastasis in gastric cancer, suggesting that both of them may play an important role in tumor progression and metastasis.


EphA2 E-cadherin Gastric cancer Immunohistochemistry 



erythropoietin-producing hepatocellular


epithelial cadherin


receptor tyrosine kinase


phosphate buffered solution


diaminobenzidine tetrachloride




matrix metalloprotease


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Copyright information

© Arányi Lajos Foundation 2008

Authors and Affiliations

  • Weijie Yuan
    • 1
  • Zhikang Chen
    • 1
  • Shaobin Wu
    • 1
  • Jie Ge
    • 1
  • Shi Chang
    • 1
  • Xianwei Wang
    • 1
  • Jingxiang Chen
    • 1
  • Zihua Chen
    • 1
  1. 1.Department of General Surgery, Xiangya HospitalCentral South UniversityChangshaPeoples Republic of China

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