Pathology & Oncology Research

, Volume 14, Issue 2, pp 205–208 | Cite as

Microscopic Peliosis of Pancreatic Islets Associated with Thrombotic Thrombocytopenic Purpura

  • Vesselin Belovejdov
  • Diana Staribratova
  • Dorian Dikov
Original Paper

Abstract

Peliosis is a rarely seen histological finding with unexplained fully etiology and pathogenesis. It is presented as cyst-like blood filled cavities. The presence of peliosis in the endocrine part of the pancreas is extremely rarely reported microscopic phenomenon. The authors provide histological, histochemical, immunohistochemical and ultrastructural investigation of microscopic peliosis in the pancreas from an autopsy case with thrombotic trombocytopenic purpura. The findings give ideas for a wide range of pathophysiological and morphogenetic comments of such an unusual morphologic presentation.

Keywords

Disseminated intravascular coagulation, pancreas Peliosis Pancreatic islets Thrombocytic thrombocytopenic purpura 

References

  1. 1.
    Corpa MVN, Bacchi MM, Bacchi CE et al (2004) Peliosis hepatis associated with lymphoplasmacytic lymphoma. Arch Pathol Lab Med 128:1283–1285PubMedGoogle Scholar
  2. 2.
    Kovacs K, Horvath E, Asa S et al (1986) Microscopic peliosis of pancreatic islets in a woman with MEN-1 syndrome. Arch Pathol Lab Med 110:607–610PubMedGoogle Scholar
  3. 3.
    Berzigotti A, Magalotti D, Zappoli P et al (2006) Peliosis hepatic as an early histological finding in idiopathic portal hypertension: a case report. World J Gastroenterol 12(22):3612–3615PubMedGoogle Scholar
  4. 4.
    Tsokos M, Erbersdobler A (2005) Pathology of peliosis. Forensic Sci Int 149 (1):25–33PubMedCrossRefGoogle Scholar
  5. 5.
    Zafrani ES, Cazier A, Baudelot AM et al (1984) Ultrastructural lesions of the liver in human peliosis. A report of 12 cases. Am J Pathol 114(3):349–359Google Scholar
  6. 6.
    Warfel KA, Ellis GH (1982) Peliosis of the spleen. Report of a case and review of the literature. Arch Pathol Lab Med 106(2):99–100PubMedGoogle Scholar
  7. 7.
    Czapar CA, Weldon-Linne CM, Moore DM et al (1986) Peliosis hepatic in acquired immunodeficiency syndrome. Arch Pathol Lab Med 110(7):611–613PubMedGoogle Scholar
  8. 8.
    Gulubova M (2002) Immunohistochemical localization of collagen Type III and Type IV, laminin, tenascin and α-smooth muscle actin (αSMA) in the human liver in peliosis. Pathol Res Pract 198:803–812PubMedCrossRefGoogle Scholar
  9. 9.
    Korner M, Gebbers J-O (2002) Peliosis of the spleen and haemolytic anemia. Histopathology 41:179–180PubMedCrossRefGoogle Scholar
  10. 10.
    Koehler JE, Sanchez MA, Garrido CS et al (1997) Molecular epidemiology of Bartonellainfections in patients with bacillary angiomatosis–peliosis. The N Eng J Med 337 (26):1876–83CrossRefGoogle Scholar
  11. 11.
    Coire CI, Horvath E, Kovacs K et al (1997) Cushing’s syndrome from an ectopic pituitary adenoma with peliosis: a histological, immunohistochemical and ultrastructural study and review of the literature. Endocr Pathol 8(1):65–74PubMedCrossRefGoogle Scholar
  12. 12.
    Lie JT (1985) Pulmonary peliosis. Arch Pathol Lab Med 109(9):878–9PubMedGoogle Scholar
  13. 13.
    Chetty R, Kennedy M, Ezzat S et al (2004) Pancreatic endocrine pathology in von Hippel-Lindau disease: an expanding spectrum of lesions. Endocrine Pathology 15(2):141–148PubMedCrossRefGoogle Scholar
  14. 14.
    Pernicone PJ, Lie JT (1987) Isolated peliosis of pancreatic islet cell adenoma. Arch Pathol Lab Med 111:690–691PubMedGoogle Scholar
  15. 15.
    Ricketts LM, Dlugous M, Luther KB et al (2007) O-fucosylation is require for ADAMTS 13 secretion. J Biol Chem 282(23):17014–23PubMedCrossRefGoogle Scholar
  16. 16.
    Girma JP (2006) Biology of von Willebrand factor. Nephrol Ther 2:s143–s148PubMedGoogle Scholar
  17. 17.
    Fina L, Molgaard HV, Robertson D et al (1990) Expression of the CD 34 gene in vascular endothelial cells. Blood 75 (12):2417–26PubMedGoogle Scholar
  18. 18.
    Delas N, Faurel JP, Wechsled B et al (1982) Association of peliosis and necrotizing vasculitis. Nouv Presse Med 25;11(37):2787Google Scholar
  19. 19.
    Galbusera M, Noris M, Remuzzi G (2006) Thrombotic thrombocytopenic purpura—then and now. Semin Thromb Hemost 32(2):81–89PubMedCrossRefGoogle Scholar
  20. 20.
    Voinchet O, Degott C, Scoazec JY et al (1988) Peliosis hepatis, nodular regenerative hyperplasia of the liver, and light-chain deposition in a patient with Waldenstrom’s macroglobulinemia. Gastroenterology 95:482–486PubMedGoogle Scholar

Copyright information

© Arányi Lajos Foundation 2008

Authors and Affiliations

  • Vesselin Belovejdov
    • 1
  • Diana Staribratova
    • 1
  • Dorian Dikov
    • 2
  1. 1.Department of General and Clinical PathologyMedical University of PlovdivPlovdivBulgaria
  2. 2.Service d’Anatomie et de Cytologie PathologiquesCentre Hospitalier de Lagny-Marne-La-ValléeParisFrance

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