Pathology & Oncology Research

, Volume 14, Issue 4, pp 411–421 | Cite as

Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL)—Clinicopathological Features Based on the Data of Two Hungarian Lymphoma Centres

  • Á. Illés
  • Zs Simon
  • E. Tóth
  • A. Rosta
  • Zs Miltényi
  • Zs Molnár
Original Paper


Clinicopathological features of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) differ from those of the classical Hodgkin lymphoma (cHL). Our aim was to examine clinical presentation, therapeutic and survival results of NLPHL patients in Hungary based on the data of two centres, and incidentally we analyzed the clinicopathological characteristics and differential diagnostic difficulties of this rare entity. We analyzed the clinical features, treatment and survival data of 536 Hodgkin lymphoma patients who had been diagnosed and primarily treated in our institutes between 1995 and 2004. Mean follow-up time was 82.7 (3–144) months of the total 536 HL patients. Sixteen (3%) of the patients were diagnosed with NLPHL, 93% of them presented with early-stage disease. None of the patients showed extranodal or splenic involvement or bulky disease. One patient received chemotherapy alone, six received only involved field radiotherapy while six underwent combined modality treatment. We applied watch and wait strategy in three cases. Overall response rate was 100% (93.75% complete). Two NLPHL cases transformed to non-Hodgkin’s lymphoma. In contrast to the classical HL, the 10-year prognosticated overall survival rate was 100 vs. 82%, the event free survival was: 75% vs. 70%. In NLPHL group there were no late or multiple relapses and none of them died. Conclusions: NLPHL is a rare disease, thus these are limited experiences with its diagnosis and treatment. Since the disease has an excellent outcomeit is very important to prefer less toxic or local therapies to reach long term survival similar to that of the normal population.


Nodular lymphocyte predominant Hodgkin lymphoma Classical Hodgkin lymphoma Differential diagnosis Immunohistochemistry Treatment Prognosis 



adriamycine, vinblastine, dacarbazine, bleomycine


autologous hemopoetic stem cell transplantation


anaplastic large cell lymphoma


bleomycine, etoposid, adriamycine, cyclophosphamide, vincristin, procarbazine, prednisolone


etoposid, prednimustin


classical Hodgkin lymphoma


combined modality treatment


undetermined complete remission


cyclophosphamide, vincristin, procarbazine/adriamycine, bleomycine, vinblastine


complete remission


cyclophosphamide, vincristin, prednisolone


dexamethasone, cytarabin, cisplatine


diffuse large B-cell non-Hodgkin lymphoma


Epstein-Barr virus


extended field radiotherapy


event-free survival


epithelial membrane antigen


European Organization for Research and Treating Cancer


European Task Force on Lymphoma


follicular dendritic cell


18-fluoro deoxyglucose


German Study Hodgkin Group


Hodgkin’s disease


high dose therapy




Hodgkin, Reed-Sternberg cells


involved field radiotherapy


involved nodal radiotherapy


International Prognostic Score


lymphocyte and histiocyte cell


lymphocyte depletion


latent membrane protein


lymphocyte predominant Hodgkin’s disease


lymphocyte rich classical Hodgkin lymphoma


mixed cellularity


nodular lymphocyte predominant Hodgkin lymphoma




nodular sclerosing


overall response rate


overall survival


positron emission tomography


partial remission


progressive transformed germinal centre


(rituximab)-cyclophosphamide, adriamycine, vincristin, prednisolone


Revised European and American Lymphoma classification


T-cell/histiocyte rich B-cell lymphoma


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Copyright information

© Arányi Lajos Foundation 2008

Authors and Affiliations

  • Á. Illés
    • 1
  • Zs Simon
    • 1
  • E. Tóth
    • 2
  • A. Rosta
    • 2
  • Zs Miltényi
    • 1
  • Zs Molnár
    • 2
  1. 1.3rd Department of Institute for Internal Medicine, Medical and Health Science CentreUniversity of DebrecenDebrecenHungary
  2. 2.National Institute of OncologyBudapestHungary

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