Genomic Characterization of the First Parechovirus in Bats

  • Chang Zhang
  • Jinliang Sheng
  • Zihan Zhao
  • Chao Yan
  • Changchun Tu
  • Biao HeEmail author

Dear Editor,

Parechoviruses (PeVs) are non-enveloped, spherical viruses of genus Parechovirus and family Picornaviridae. Within the capsid is a naked monopartite, linear, single-stranded positive-sense RNA genome of 7.3 kb, comprising a single long open reading frame (ORF) encoding a polyprotein containing regions P1, P2, and P3. The P1 region encodes three structural proteins (VP0, VP3, and VP1); P2 and P3, non-structural proteins (P2 encoding proteins 2A, 2B, and 2C, and P3 encoding proteins 3A, 3B, 3C, and 3D) (ICTV 2018). PeVs are classified into four species: Parechovirus A, is composed of human parechoviruses (HPeVs) identified worldwide, causing gastrointestinal or respiratory diseases and being implicated in myocarditis and encephalitis (Harvala and Simmonds 2009); Parechovirus B and C have been reported in rodents, including Ljungan viruses (LVs) in bank voles and Sebokele virus (SEBV) in African wood mice (Niklasson et al.1999; Joffret et al.2013); Parechovirus Dcomprises a...



This work was supported by the NSFC-Xinjiang joint fund (U1503283).

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Animal and Human Rights Statement

The sampling of bats was approved by the Administrative Committee on Animal Welfare of the Military Veterinary Institute, Academy of Military Medical Sciences, China (Laboratory Animal Care and Use Committee Authorization, Permit No. JSY-DW-2015-01).

Supplementary material

12250_2019_108_MOESM1_ESM.pdf (128 kb)
Supplementary material 1 (PDF 129 kb)


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Copyright information

© Wuhan Institute of Virology, CAS 2019

Authors and Affiliations

  1. 1.College of Animal ScienceFujian A&F UniversityFuzhouChina
  2. 2.Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary InstituteAcademy of Military Medical SciencesChangchunChina
  3. 3.College of Animal Science and TechnologyShihezi UniversityShiheziChina
  4. 4.Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and ZoonosisYangzhouChina

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