Advertisement

Genomic Characterization of the First Parechovirus in Bats

  • Chang Zhang
  • Jinliang Sheng
  • Zihan Zhao
  • Chao Yan
  • Changchun Tu
  • Biao HeEmail author
Letter

Dear Editor,

Parechoviruses (PeVs) are non-enveloped, spherical viruses of genus Parechovirus and family Picornaviridae. Within the capsid is a naked monopartite, linear, single-stranded positive-sense RNA genome of 7.3 kb, comprising a single long open reading frame (ORF) encoding a polyprotein containing regions P1, P2, and P3. The P1 region encodes three structural proteins (VP0, VP3, and VP1); P2 and P3, non-structural proteins (P2 encoding proteins 2A, 2B, and 2C, and P3 encoding proteins 3A, 3B, 3C, and 3D) (ICTV 2018). PeVs are classified into four species: Parechovirus A, is composed of human parechoviruses (HPeVs) identified worldwide, causing gastrointestinal or respiratory diseases and being implicated in myocarditis and encephalitis (Harvala and Simmonds 2009); Parechovirus B and C have been reported in rodents, including Ljungan viruses (LVs) in bank voles and Sebokele virus (SEBV) in African wood mice (Niklasson et al.1999; Joffret et al.2013); Parechovirus Dcomprises a...

Notes

Acknowledgements

This work was supported by the NSFC-Xinjiang joint fund (U1503283).

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Animal and Human Rights Statement

The sampling of bats was approved by the Administrative Committee on Animal Welfare of the Military Veterinary Institute, Academy of Military Medical Sciences, China (Laboratory Animal Care and Use Committee Authorization, Permit No. JSY-DW-2015-01).

Supplementary material

12250_2019_108_MOESM1_ESM.pdf (128 kb)
Supplementary material 1 (PDF 129 kb)

References

  1. Drexler JF, Corman VM, Lukashev AN, van den Brand JM, Gmyl AP, Brunink S, Rasche A, Seggewibeta N, Feng H, Leijten LM, Vallo P, Kuiken T, Dotzauer A, Ulrich RG, Lemon SM, Drosten C (2015) Evolutionary origins of hepatitis A virus in small mammals. Proc Natl Acad Sci USA 112:15190–15195CrossRefGoogle Scholar
  2. Harvala H, Simmonds P (2009) Human parechoviruses: biology, epidemiology and clinical significance. J Clin Virol 45:1–9CrossRefGoogle Scholar
  3. ICTV 2018. ICTV online (10th) report (2018). Accessed 21 October 2018. https://talk.ictvonline.org/taxonomy
  4. Joffret ML, Bouchier C, Grandadam M, Zeller H, Maufrais C, Bourhy H, Despres P, Delpeyroux F, Dacheux L (2013) Genomic characterization of Sebokele virus 1 (SEBV1) reveals a new candidate species among the genus Parechovirus. J Gen Virol 94:1547–1553CrossRefGoogle Scholar
  5. Niklasson B, Kinnunen L, Hornfeldt B, Horling J, Benemar C, Hedlund KO, Matskova L, Hyypia T, Winberg G (1999) A new picornavirus isolated from bank voles (Clethrionomys glareolus). Virology 255:86–93CrossRefGoogle Scholar
  6. Smits SL, Raj VS, Oduber MD, Schapendonk CM, Bodewes R, Provacia L, Stittelaar KJ, Osterhaus AD, Haagmans BL (2013) Metagenomic analysis of the ferret fecal viral flora. PLoS ONE 8:e71595CrossRefPubMedCentralGoogle Scholar
  7. Wu Z, Yang L, Ren X, He G, Zhang J, Yang J, Qian Z, Dong J, Sun L, Zhu Y, Du J, Yang F, Zhang S, Jin Q (2016) Deciphering the bat virome catalog to better understand the ecological diversity of bat viruses and the bat origin of emerging infectious diseases. ISME J 10:609–620CrossRefGoogle Scholar
  8. Yinda CK, Zell R, Deboutte W, Zeller M, Conceicao-Neto N, Heylen E, Maes P, Knowles NJ, Ghogomu SM, Van Ranst M, Matthijnssens J (2017) Highly diverse population of Picornaviridae and other members of the Picornavirales, in Cameroonian fruit bats. BMC Genom 18:249CrossRefGoogle Scholar
  9. Zhang C, Yan C, Zhao Z, Tu C, Qu Y, Sheng J, He B (2018) Viral metagenomic analyses of bats in Xinjiang, China. Chin J Virol 34:896–903 (in Chinese) Google Scholar

Copyright information

© Wuhan Institute of Virology, CAS 2019

Authors and Affiliations

  1. 1.College of Animal ScienceFujian A&F UniversityFuzhouChina
  2. 2.Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary InstituteAcademy of Military Medical SciencesChangchunChina
  3. 3.College of Animal Science and TechnologyShihezi UniversityShiheziChina
  4. 4.Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and ZoonosisYangzhouChina

Personalised recommendations