Genomic Characterization of the First Parechovirus in Bats
Parechoviruses (PeVs) are non-enveloped, spherical viruses of genus Parechovirus and family Picornaviridae. Within the capsid is a naked monopartite, linear, single-stranded positive-sense RNA genome of 7.3 kb, comprising a single long open reading frame (ORF) encoding a polyprotein containing regions P1, P2, and P3. The P1 region encodes three structural proteins (VP0, VP3, and VP1); P2 and P3, non-structural proteins (P2 encoding proteins 2A, 2B, and 2C, and P3 encoding proteins 3A, 3B, 3C, and 3D) (ICTV 2018). PeVs are classified into four species: Parechovirus A, is composed of human parechoviruses (HPeVs) identified worldwide, causing gastrointestinal or respiratory diseases and being implicated in myocarditis and encephalitis (Harvala and Simmonds 2009); Parechovirus B and C have been reported in rodents, including Ljungan viruses (LVs) in bank voles and Sebokele virus (SEBV) in African wood mice (Niklasson et al.1999; Joffret et al.2013); Parechovirus Dcomprises a...
This work was supported by the NSFC-Xinjiang joint fund (U1503283).
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
Animal and Human Rights Statement
The sampling of bats was approved by the Administrative Committee on Animal Welfare of the Military Veterinary Institute, Academy of Military Medical Sciences, China (Laboratory Animal Care and Use Committee Authorization, Permit No. JSY-DW-2015-01).
- Drexler JF, Corman VM, Lukashev AN, van den Brand JM, Gmyl AP, Brunink S, Rasche A, Seggewibeta N, Feng H, Leijten LM, Vallo P, Kuiken T, Dotzauer A, Ulrich RG, Lemon SM, Drosten C (2015) Evolutionary origins of hepatitis A virus in small mammals. Proc Natl Acad Sci USA 112:15190–15195CrossRefGoogle Scholar
- ICTV 2018. ICTV online (10th) report (2018). Accessed 21 October 2018. https://talk.ictvonline.org/taxonomy
- Zhang C, Yan C, Zhao Z, Tu C, Qu Y, Sheng J, He B (2018) Viral metagenomic analyses of bats in Xinjiang, China. Chin J Virol 34:896–903 (in Chinese) Google Scholar