Virologica Sinica

, Volume 34, Issue 3, pp 342–345 | Cite as

Rift Valley Fever Virus and Yellow Fever Virus in Urine: A Potential Source of Infection

  • Meng Li
  • Beibei Wang
  • Liqiang Li
  • Gary Wong
  • Yingxia Liu
  • Jinmin Ma
  • Jiandong Li
  • Hongzhou Lu
  • Mifang Liang
  • Ang Li
  • Xiuqing Zhang
  • Yuhai BiEmail author
  • Hui ZengEmail author

Dear Editor,

In recent years, the incidence of human infections caused by emerging or re-emerging pathogens has rapidly increased. Diseases that were once regional now have the ability to spread globally in a short amount of time and pose a wider threat to public health (Weaver et al.2018). Yellow fever virus (YFV, family Flaviviridae, genus Flavivirus) is a mosquito-borne flavivirus that causes yellow fever in humans and has been endemic in Africa and Latin America for many years (Domingo et al. 2018). The most recent large-scale outbreak of YFV occurred in Brazil in which the mortality rate as of February 28, 2018 is 32.78% (WHO 2018). Rift Valley fever virus (RVFV, family Bunyaviridae, genus Phlebovirus) is another mosquito-borne virus and primarily circulates in Africa and the Middle East, and in recent years in Europe (Mansfield et al. 2015). During the initial stage of infection, most patients infected with YFV or RVFV present nonspecific symptoms such as fever, headache, and...



This work is supported by grants from the National Science and Technology Major Project of China (2016ZX10004222 and 2016YFC1200800), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB29010102), Sanming Project of Medicine in Shenzhen (SZSM201412003), Shenzhen Municipal Government of China (JCYJ20160427151920801) and Beijing Municipal Science & Technology Commission (Z161100000116049), and the National Natural Science Foundation of China (NSFC) International Cooperation and Exchange Program (816110193). Y.B. is supported by the NSFC Outstanding Young Scholars (31822055) and Youth Innovation Promotion Association of Chinese Academy of Sciences (CAS) (2017122).

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Animal and Human Rights Statement

Informed consent was obtained from all patients for the collection and use of all clinical specimens. This article does not contain any studies with animal subjects performed by any of the authors.

Supplementary material

12250_2019_96_MOESM1_ESM.pdf (588 kb)
Supplementary material 1 (PDF 588 kb)


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Copyright information

© Wuhan Institute of Virology, CAS 2019

Authors and Affiliations

  1. 1.BGI Education CenterUniversity of Chinese Academy of SciencesShenzhenChina
  2. 2.Beijing Key Laboratory of Emerging Infectious DiseasesInstitute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical UniversityBeijingChina
  3. 3.China National GeneBank, BGI-ShenzhenShenzhenChina
  4. 4.Shenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious DiseasesState Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People’s HospitalShenzhenChina
  5. 5.Institute Pasteur of Shanghai, Chinese Academy of SciencesShanghaiChina
  6. 6.Département de Microbiologie-Infectiologie et d’immunologieUniversité LavalQuébecCanada
  7. 7.Department of Internal MedicineShanghai Medical College, Fudan UniversityShanghaiChina
  8. 8.Key Laboratory of Medical Virology and Viral DiseasesMinistry of Health, National Institute for Viral Disease Control and Prevention (IVDC), Chinese Center for Disease Control and Prevention, (China CDC)BeijingChina
  9. 9.CAS Key Laboratory of Pathogenic Microbiology and ImmunologyInstitute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of SciencesBeijingChina

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