Histopathological Features and Viral Antigen Distribution in the Lung of Fatal Patients with Enterovirus 71 Infection
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Enterovirus 71 (EV71) infection causes hand-foot-and-mouth disease (HFMD) in infants and children. Patients with HFMD usually have good prognosis; however, in some extreme cases the infection can be accompanied by central nervous system diseases, eventually leading to cardiorespiratory failure, and even death. Currently, EV71 has become one of the most important pathogens infecting central nervous system, after poliovirus. Previous studies have shown that lung injury in patients with HFMD is associated with neurogenic pulmonary edema (NPE) after EV71 infection of the brainstem, rather than with direct viral invasion (Jiang et al.2012). This might be because EV71 was not isolated and inflammatory cell infiltration rarely occurred in lung and lung injured tissues (Kao et al.2004; Jiang et al.2012). EV71 can be transmitted through respiratory tract and cause upper respiratory tract infection, such as herpangina; nevertheless, the translocation route from the upper...
This study was supported by the Guangxi Natural Science Foundation Grant (2014GXNSFAA118200).
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Conflict of interest
The authors declare that they have no conflict of interest.
Animal and Human Rights Statement
The study was approved by the Medical Ethics Committee of Guangxi Medical University. Written informed consents were obtained from all the patients, or their guardians and families prior to the study.