Serological Evidence of Bat SARS-Related Coronavirus Infection in Humans, China
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Severe acute respiratory syndrome coronavirus (SARS-CoV) is the causative agent of the 2002–2003 SARS pandemic, which resulted in more than 8000 human infections worldwide and an approximately 10% fatality rate (Ksiazek et al. 2003; Peiris et al. 2004). The virus infects both upper airway and alveolar epithelial cells, resulting in mild to severe lung injury in humans (Peiris et al. 2003).
During the SARS outbreak investigation, epidemiological evidence of a zoonotic origin of SARS-CoV was identified (Xu et al. 2004). Isolation of SARS-related coronavirus (SARSr-CoVs) from masked palm civets and the detection of SARS-CoV infection in humans working at wet markets where civets were sold suggested that masked palm civets could serve as a source of human infection (Guan et al. 2003). Subsequent work identified genetically diverse SARSr-CoVs in Chinese horseshoe bats (Rhinolophus sinicus) in a county of Yunnan Province, China and provided strong evidence that bats are the...
This study was jointly funded by the National Natural Science Foundation of China Grant (81290341) to ZLS; the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (Award Number R01AI110964) to PD and ZLS, United States Agency for International Development (USAID) Emerging Pandemic Threats PREDICT project Grant (Cooperative Agreement No. AID-OAA-A-14-00102) to PD; and Singapore NRF-CRP Grant (NRF2012NRF-CRP001–056) and CD-PHRG Grant (CDPHRG/0006/2014) to LFW.
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
Animal and Human Rights
This study was approved by the Wuhan Institute of Virology Institutional Review Board (China) and by Hummingbird IRB (USA).
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