NAP1L1 Regulates Hepatitis C Virus Entry and Interacts with NS3
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Mammalian cells encode five members of the nucleosome assembly protein 1 (NAP1) family of proteins including nucleosome assembly protein 1-like 1 (NAP1L1), NAP1L2, NAP1L3, NAP1L4 and NAP1L5 (Attia et al. 2011). NAP1L1 is ubiquitously expressed and has been implicated in several processes of transcription and DNA replication, such as the nucleosome assembly, nucleosome sliding, transcriptional activation through chromatin remodeling, and nucleocytoplasmic shuttling of histones (Lee et al. 2017; Moshkin et al. 2009; Zlatanova et al. 2007). Furthermore, NAP1L1 is involved in the life cycle of several DNA viruses (EBV, KSHV and HPV) (Gupta et al. 2016; Rehtanz et al. 2004; Wang and Frappier 2009) and retroviruses (HIV and HTLV) (Sharma and Nyborg 2008; Vardabasso et al. 2008). An interesting but yet unanswered question is whether NAP1L1 is involved in the life cycle of RNA viruses.
Hepatitis C virus (HCV) encoded a 9.6-kb positive-sense RNA genome and is classified as the Hepacivirus...
This work was supported by grants from the Beijing Natural Science Foundation (7164283), National Natural Science Foundation of China (81471955, 81672035), PUMC youth Fund (3332016085), the Fundamental Research Funds for the Central Universities, CAMS Innovation Fund for Medical Sciences (CIFMS) (2016-I2M-3-020), and Program for Changjiang Scholars and Innovative Research Team in University (IRT13007). We thank Charles Rice, Francis Chisari, Ping Zhao, Masanori Ikeda, Nobuyuki Kato and Takaji Wakita for reagents.
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Conflict of interest
The authors declare that there are no conflicts of interest.
Animal and Human Rights Statement
This article does not contain any studies with human or animal subjects performed by any of the authors.
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