Virologica Sinica

, Volume 33, Issue 1, pp 96–99 | Cite as

Avian Influenza A (H7N9) Virus in a Wild Land Bird in Central China, Late 2015

  • Yanfeng Yao
  • Tao Zhang
  • Wenhai Yang
  • Zhiyong Shao
  • Bin He
  • Xiabing Chen
  • Lijun Wu
  • Erguang Jin
  • Haizhou Liu
  • Jianjun ChenEmail author
  • Jie ChenEmail author

Dear Editor,

In early 2013, the first case of a human infection with avian influenza A (H7N9) virus was reported in the Yangtze River Delta region of China (Liu et al. 2013). Since early 2013, a total of 1533 laboratory-confirmed human infections with avian H7N9 viruses have been reported to the World Health Organization (, with five epidemic waves of this virus occurring in China. Human infections with the highly pathogenic H7N9 influenza virus have emerged particularly in China (Zhang et al. 2017). The increasing numbers of human infections with H7N9 influenza viruses raises concerns that these viruses will continue to be a potential pandemic threat to public health.

It has been shown that the H7N9 virus responsible for the 2013 Chinese outbreak originated from gene reassortment among H7, N9 and H9N2 avian influenza viruses (AIVs), and it appears that the internal genes of the H7N9 viruses are most closely related to a wild land...



This research is supported by grants from the National Natural Science Foundation of China (31400787, 31570026), Hubei Provincial Natural Science Foundation of China (2016CFC743), Wuhan Youth Science and technology plan (2016070204010104) and Special Project of Ministry of Science and Technology (2013FY113500).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

Animal and Human Rights Statement

The manuscript did not use animal and human subjects since fecal samples were collected in the environment.

Supplementary material

12250_2018_1_MOESM1_ESM.pdf (2 mb)
Supplementary material 1 (PDF 2013 kb)


  1. Bi Y, Xie Q, Zhang S, Li Y, Xiao H, Jin T, Zheng W, Li J, Jia X, Sun L, Liu J, Qin C, Gao GF, Liu W (2015) Assessment of the internal genes of influenza A (H7N9) virus contributing to high pathogenicity in mice. J Virol 89:2–13CrossRefPubMedGoogle Scholar
  2. Chen Y, Liang W, Yang S, Wu N, Gao H, Sheng J, Yao H, Wo J, Fang Q, Cui D, Li Y, Yao X, Zhang Y, Wu H, Zheng S, Diao H, Xia S, Zhang Y, Chan K-H, Tsoi H-W, Teng JL-L, Song W, Wang P, Lau S-Y, Zheng M, Chan JF-W, To KK-W, Chen H, Li L, Yuen K-Y (2013) Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome. Lancet 381:1916–1925CrossRefPubMedGoogle Scholar
  3. Cheung PP, Leung YH, Chow CK, Ng CF, Tsang CL, Wu YO, Ma SK, Sia SF, Guan Y, Peiris JS (2009) Identifying the species-origin of faecal droppings used for avian influenza virus surveillance in wild-birds. J Clin Virol 46:90–93CrossRefPubMedPubMedCentralGoogle Scholar
  4. Gambaryan AS, Matrosovich TY, Philipp J, Munster VJ, Fouchier RAM, Cattoli G, Capua I, Krauss SL, Webster RG, Banks J, Bovin NV, Klenk H-D, Matrosovich MN (2012) Receptor-binding profiles of H7 subtype influenza viruses in different host species. J Virol 86:4370–4379CrossRefPubMedPubMedCentralGoogle Scholar
  5. Govorkova EA, Baranovich T, Seiler P, Armstrong J, Burnham A, Guan Y, Peiris M, Webby RJ, Webster RG (2013) Antiviral resistance among highly pathogenic influenza A (H5N1) viruses isolated worldwide in 2002–2012 shows need for continued monitoring. Antiviral Res 98:297–304CrossRefPubMedPubMedCentralGoogle Scholar
  6. Hoffmann E, Stech J, Guan Y, Webster RG, Perez DR (2001) Universal primer set for the full-length amplification of all influenza A viruses. Arch Virol 146:2275–2289CrossRefPubMedGoogle Scholar
  7. Liu D, Shi W, Shi Y, Wang D, Xiao H, Li W, Bi Y, Wu Y, Li X, Yan J, Liu W, Zhao G, Yang W, Wang Y, Ma J, Shu Y, Lei F, Gao GF (2013) Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses. Lancet 381:1926–1932CrossRefPubMedGoogle Scholar
  8. Liu M, Song TR, Hua S, Wu AP, Jiang TJ (2015) Computational analysis of antigenic epitopes of avian influenza A (H7N9) viruses. Sci China Life Sci 58:687–693CrossRefPubMedGoogle Scholar
  9. Pinto LH, Holsinger LJ, Lamb RA (1992) Influenza virus M2 protein has ion channel activity. Cell 69:517–528CrossRefPubMedGoogle Scholar
  10. Siengsanan-Lamont J, Robertson I, Blacksell SD, Ellis T, Fenwick S, Saengchoowong S, Suwanpukdee S, Yongyuttawichai P, Sariya L, Prompiram P, Chaichoun K, Wiriyarat W, Pothieng D, Ratanakorn P (2011) Virological and molecular epidemiological investigations into the role of wild birds in the epidemiology of influenza A/H5N1 in central Thailand. Vet Microbiol 148:213–218CrossRefPubMedGoogle Scholar
  11. Stamatakis A (2014) RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics 30:1312–1313CrossRefPubMedPubMedCentralGoogle Scholar
  12. Wang D, Yang L, Zhu W, Zhang Y, Zou S, Bo H, Gao R, Dong J, Huang W, Guo J, Li Z, Zhao X, Li X, Xin L, Zhou J, Chen T, Dong L, Wei H, Li X, Liu L, Tang J, Lan Y, Yang J, Shu Y (2016) Two outbreak sources of influenza A (H7N9) viruses have been established in China. J Virol 90:5561–5573CrossRefPubMedPubMedCentralGoogle Scholar
  13. Wu Y, Bi Y, Vavricka CJ, Sun X, Zhang Y, Gao F, Zhao M, Xiao H, Qin C, He J, Liu W, Yan J, Qi J, Gao GF (2013) Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses. Cell Res 23:1347–1355CrossRefPubMedPubMedCentralGoogle Scholar
  14. Xiong X, Martin SR, Haire LF, Wharton SA, Daniels RS, Bennett MS, McCauley JW, Collins PJ, Walker PA, Skehel JJ, Gamblin SJ (2013) Receptor binding by an H7N9 influenza virus from humans. Nature 499:496–499CrossRefPubMedGoogle Scholar
  15. Zhang F, Bi Y, Wang J, Wong G, Shi W, Hu F, Yang Y, Yang L, Deng X, Jiang S, He X, Liu Y, Yin C, Zhong N, Gao GF (2017) Human infections with recently-emerging highly pathogenic H7N9 avian influenza virus in China. J Infect 75:71–75CrossRefPubMedGoogle Scholar
  16. Zhao B, Zhang X, Zhu W, Teng Z, Yu X, Gao Y, Wu D, Pei E, Yuan Z, Yang L, Wang D, Shu Y, Wu F (2014) Novel avian influenza A(H7N9) virus in tree sparrow, Shanghai, China, 2013. Emerg Infect Dis 20:850–853CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Wuhan Institute of Virology, CAS and Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Institute of Animal Husbandry and Veterinary ScienceWuhan Academy of Agricultural Science and TechnologyWuhanChina
  2. 2.Department of Earth System ScienceTsinghua UniversityBeijingChina
  3. 3.CAS Key Laboratory of Special Pathogens and BiosafetyChinese Academy of SciencesWuhanChina

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