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Virologica Sinica

, Volume 32, Issue 1, pp 97–100 | Cite as

Antigenicity of severe fever with thrombocytopenia syndrome virus nucleocapsid protein and its potential application in the virus serodiagnosis

  • Abulimiti Moming
  • Yujiang Zhang
  • Chenchen Chang
  • Huan Yu
  • Meifang Wang
  • Zhihong Hu
  • Fei DengEmail author
  • Surong SunEmail author
Letter

Dear Editor,

Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly identified viral pathogen of the genus Phlebovirus in the family Bunyaviridae (Sun et al., 2012). SFTSV was first identified from patient serum samples in China (Li et al., 2013; Ning et al., 2015). SFTSV can cause a severe hemorrhagic fever-like disease with a reported case fatality rate ranging from 2.5% to 30%, representing a significant public health problem, (Liu et al., 2013). However, the pathogenesis of STFSV remains unknown, and there are no vaccines or specific antivirals available (Ning et al., 2015). The SFTSV genome consists of three negative single-stranded RNA segments, including the L, M, and S segments (Yu et al., 2011). The S segment encodes the nucleoprotein (NP), which was shown to be highly immunogenic and is conserved among all isolates of phleboviruses (Xu et al., 2011; Martin et al., 2010; Fukushi et al., 2012). Antibodies against the SFTSV NP are commonly detected early after...

Supplementary material

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Antigenicity of severe fever with thrombocytopenia syndrome virus nucleocapsid protein and its potential application in the virus serodiagnosis

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Copyright information

© Wuhan Institute of Virology, CAS and Springer Science+Business Media Singapore 2017

Authors and Affiliations

  • Abulimiti Moming
    • 1
  • Yujiang Zhang
    • 2
  • Chenchen Chang
    • 1
  • Huan Yu
    • 1
  • Meifang Wang
    • 1
  • Zhihong Hu
    • 3
  • Fei Deng
    • 3
    Email author
  • Surong Sun
    • 1
    Email author
  1. 1.Xinjiang Key Laboratory of Biological Resources and Geneti ering, College of Life Science and TechnologyXinjiang UniversityUrumqiChina
  2. 2.Center for Disease Control and Prevention of Xinjiang Uygur Autonomous RegionUrumqiChina
  3. 3.State Key Laboratory of Virology, Wuhan Institute of VirologyChinese Academy of SciencesWuhanChina

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