Antigenicity of severe fever with thrombocytopenia syndrome virus nucleocapsid protein and its potential application in the virus serodiagnosis
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Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly identified viral pathogen of the genus Phlebovirus in the family Bunyaviridae (Sun et al., 2012). SFTSV was first identified from patient serum samples in China (Li et al., 2013; Ning et al., 2015). SFTSV can cause a severe hemorrhagic fever-like disease with a reported case fatality rate ranging from 2.5% to 30%, representing a significant public health problem, (Liu et al., 2013). However, the pathogenesis of STFSV remains unknown, and there are no vaccines or specific antivirals available (Ning et al., 2015). The SFTSV genome consists of three negative single-stranded RNA segments, including the L, M, and S segments (Yu et al., 2011). The S segment encodes the nucleoprotein (NP), which was shown to be highly immunogenic and is conserved among all isolates of phleboviruses (Xu et al., 2011; Martin et al., 2010; Fukushi et al., 2012). Antibodies against the SFTSV NP are commonly detected early after...
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