Retromer localizes to autophagosomes during HCV replication
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Hepatitis C virus (HCV) is a positive-strand RNA virus that belongs to the genus Hepacivirus within the Flaviviridae family. HCV causes chronic liver diseases, and 185 million people are infected (Messina et al., 2015). Currently, there is no approved vaccine to prevent hepatitis C. HCV induces autophagy through elevating reactive oxygen species (ROS) levels via the unfolded protein response (UPR) or via direct interference with the autophagic pathway, which is crucial for the initiation of the HCV infection process (Dreux et al., 2009; Estrabaud et al., 2011; Huang et al., 2013). Autophagy is a highly conserved intracellular process that targets cytosolic components for lysosomal degradation and is initiated by the formation of double-membrane vesicles called autophagosomes (Sica et al., 2015). The autophagosome ultimately fuses with a lysosome to form an autolysosome (Feng et al., 2014).
The retromer complex is a key part of the endosomal protein sorting machinery that...
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