Relationship of HLA-A,-Cw polymorphisms with HIV/AIDS in Chinese Yi ethnic group of Sichuan province
The relationship of HLA-A,-Cw alleles on HIV infection and AIDS disease progression in the Chinese Yi ethnic group of Sichuan province were investigated. The genetic polymorphisms of HLA-A,-Cw alleles of 102 unrelated healthy Chinese Yi ethnic individuals, 68 HIV-1 infected and 21 HIV positive long-time survivors were typed by PCR-SSP assay. Statistic significance was determined by the x2 test with the SPSS software. No significant differences were observed between the HLA-A,-Cw alleles of the 68 HIV-1 infected and 102 non-infected Chinese Yi control individuals. Whereas the prevalence of A*3601,Cw*14(01-03)and Cw*0304 was significantly higher in 21 long time survivors compared with 102 healthy controls with P values of 0.016, 0.016 and 0.000 by x2 or the Fisher exact test respectively. The result implies that A*3601,Cw*14(01-03) and Cw*0304 may be associated with slow AIDS disease progression in the Chinese Yi ethnic group, further studies on this association may yield insight on the pathogenesis of HIV-1 infection.
Key wordsChinese Yi Ethnic Group HLA-A HLA-Cw HIV/AIDS Association
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- 4.Gore S M, Hutchinson S, Brettle R P, et al. Study requirements for investigating HLA-associated progression of HIV disease, and review. Quant J Med, 1999, 92: 609–617.Google Scholar
- 5.Guo Z, Li X, He Y. 1996. Data Analysis of Medical Genetics and Genetic Epidemiology. Haerbing: Helongjiang Science and Technology Press, p1–p50.Google Scholar
- 9.Sun Z R, Shang H, Zhang Y Z, et al. 2003. Studies of potential linkage between HLA class I alleles and HIV infection. Chin J Micro Immunol, 23(3): 356–358.Google Scholar