Virologica Sinica

, Volume 22, Issue 4, pp 301–306 | Cite as

Relationship of HLA-A,-Cw polymorphisms with HIV/AIDS in Chinese Yi ethnic group of Sichuan province

  • Hong Kun-xue
  • Lu Xiao-zhi
  • Qin Guang-ming
  • Chen Jian-ping
  • Ruan Yu-hua
  • Xing Hui
  • Zhu Jia-hong
  • Shao Yi-ming
Article

Abstract

The relationship of HLA-A,-Cw alleles on HIV infection and AIDS disease progression in the Chinese Yi ethnic group of Sichuan province were investigated. The genetic polymorphisms of HLA-A,-Cw alleles of 102 unrelated healthy Chinese Yi ethnic individuals, 68 HIV-1 infected and 21 HIV positive long-time survivors were typed by PCR-SSP assay. Statistic significance was determined by the x2 test with the SPSS software. No significant differences were observed between the HLA-A,-Cw alleles of the 68 HIV-1 infected and 102 non-infected Chinese Yi control individuals. Whereas the prevalence of A*3601,Cw*14(01-03)and Cw*0304 was significantly higher in 21 long time survivors compared with 102 healthy controls with P values of 0.016, 0.016 and 0.000 by x2 or the Fisher exact test respectively. The result implies that A*3601,Cw*14(01-03) and Cw*0304 may be associated with slow AIDS disease progression in the Chinese Yi ethnic group, further studies on this association may yield insight on the pathogenesis of HIV-1 infection.

Key words

Chinese Yi Ethnic Group HLA-A HLA-Cw HIV/AIDS Association 

CLC number

R373 

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Copyright information

© Wuhan Institute of Virology, CAS 2007

Authors and Affiliations

  • Hong Kun-xue
    • 1
  • Lu Xiao-zhi
    • 2
  • Qin Guang-ming
    • 3
  • Chen Jian-ping
    • 1
  • Ruan Yu-hua
    • 1
  • Xing Hui
    • 1
  • Zhu Jia-hong
    • 2
  • Shao Yi-ming
    • 1
  1. 1.National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina
  2. 2.Wuhan Institute of Biological ProductsWuhanChina
  3. 3.Sichuan Center for Disease Control and PreventionChenduChina

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