Pharmaceutical Application of Fast Raman Hyperspectral Imaging with Compressive Detection Strategy
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This article reports a new Raman imaging instrument based on liquid crystal spatial light modulator compressive detection (LC-SLM-CD) strategy that could provide a fast way of testing the composition of solid formulations. In this study, the LC-SLM-CD strategy is employed to investigate the qualitative and relative quantitative distribution of two commonly used ingredients, acetaminophen and lactose in a pharmaceutical tablet. The spatial distribution of each component is formed based on the responses of the samples to the partial least squares filters built into the instrument. This technique has proven to be a fast and feasible technique for noninvasive determination of blend quality and for determination of relative abundances of each component in a tablet.
KeywordsRaman spectroscopy Hyperspectral imaging Compressive detection PLS
The present work was financially supported by NSF-Engineering Research Center for Structured Organic Particulate Systems (ERC-SOPS, EEC-0540855). The development of this instrument was supported by a grant from the National Science Foundation (grant IDBR 0754740).