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Pharmaceutical Application of Fast Raman Hyperspectral Imaging with Compressive Detection Strategy

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Abstract

This article reports a new Raman imaging instrument based on liquid crystal spatial light modulator compressive detection (LC-SLM-CD) strategy that could provide a fast way of testing the composition of solid formulations. In this study, the LC-SLM-CD strategy is employed to investigate the qualitative and relative quantitative distribution of two commonly used ingredients, acetaminophen and lactose in a pharmaceutical tablet. The spatial distribution of each component is formed based on the responses of the samples to the partial least squares filters built into the instrument. This technique has proven to be a fast and feasible technique for noninvasive determination of blend quality and for determination of relative abundances of each component in a tablet.

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Acknowledgments

The present work was financially supported by NSF-Engineering Research Center for Structured Organic Particulate Systems (ERC-SOPS, EEC-0540855). The development of this instrument was supported by a grant from the National Science Foundation (grant IDBR 0754740).

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Authors and Affiliations

  1. Department of Chemistry, Purdue University, W. Lafayette, IN, 47907, USA

    Derya Cebeci-Maltaş, Ping Wang & Dor Ben-Amotz

  2. Department of Industrial and Physical Pharmacy, Purdue University, W. Lafayette, IN, 47907, USA

    Ryan McCann & Rodolfo Pinal

  3. Department of Chemistry, University of Puerto Rico, Mayagüez, PR, 00680, Puerto Rico

    Rodolfo Romañach

Authors
  1. Derya Cebeci-Maltaş
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  2. Ryan McCann
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  3. Ping Wang
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  4. Rodolfo Pinal
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  5. Rodolfo Romañach
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  6. Dor Ben-Amotz
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Corresponding author

Correspondence to Derya Cebeci-Maltaş.

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Cebeci-Maltaş, D., McCann, R., Wang, P. et al. Pharmaceutical Application of Fast Raman Hyperspectral Imaging with Compressive Detection Strategy. J Pharm Innov 9, 1–4 (2014). https://doi.org/10.1007/s12247-013-9168-8

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  • DOI: https://doi.org/10.1007/s12247-013-9168-8

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