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Journal of Pharmaceutical Innovation

, Volume 4, Issue 4, pp 187–197 | Cite as

Near-infrared Spectroscopy for the In-line Characterization of Powder Voiding Part I: Development of the Methodology

  • Jorge Ropero
  • Lauren Beach
  • Manel Alcalà
  • Raizza Rentas
  • Rajesh N. Davé
  • Rodolfo J. RomañachEmail author
Research Article

Abstract

In-line near-infrared spectroscopy (NIR) spectra were acquired and analyzed to assess the relationship between physical and chemical properties of voiding powders and their spectral changes. NIR spectra were obtained for powders voiding from a conical glass funnel while the powder flow was recorded with a digital camera. Two different approaches using in-line NIR spectra were developed to measure the flow interruptions in the powder voiding process. The first approach uses the noise in the spectra and the second is based on the baseline changes. The new method was also used to evaluate the effects of humidity on the flow of microcrystalline cellulose samples and to evaluate the effect of mixing method on the flow properties of the blends obtained. The method described may be applied to other applications that involve powder flow, and the same spectra may be used to determine drug concentration.

Keywords

Powder flow Near-infrared spectroscopy In-line monitoring Process analytical technology Quality by design 

Notes

Acknowledgements

Authors acknowledge the support of National Science Foundation (ERC research grant: EEC-0540855) for conducting this research work.

Supplementary material

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(WMV 854 kb)

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Copyright information

© International Society for Pharmaceutical Engineering 2009

Authors and Affiliations

  • Jorge Ropero
    • 1
  • Lauren Beach
    • 2
  • Manel Alcalà
    • 3
  • Raizza Rentas
    • 1
  • Rajesh N. Davé
    • 2
  • Rodolfo J. Romañach
    • 1
    Email author
  1. 1.Department of ChemistryUniversity of Puerto RicoMayagüezPuerto Rico
  2. 2.Department of Chemical EngineeringNew Jersey Institute of TechnologyNewarkUSA
  3. 3.Grup de Quimiometria Aplicada, Departament de Química (U. Analítica), Facultat de CiènciesUniversitat Autònoma de BarcelonaBellaterraSpain

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