Laboratory diagnosis of spinal tuberculosis: past and present
Spinal tuberculosis often has an indolent course and can be a diagnostic challenge. Timely laboratory diagnosis helps to start early treatment and prevents occurrence of serious complications. Techniques such as Ziehl-Neelsen staining, histopathology and culture on solid media have been conventionally used for laboratory diagnosis of tuberculosis. Availability of liquid TB culture and molecular diagnostic tests has helped to increase the sensitivity of diagnosis and give rapid results. However, these diagnostic aids demand technical expertise and stringent quality control. High cost also limits the use of these newer techniques in poor countries which respresent the greatest reservoir of tuberculosis.
Keywordstuberculosis spine AFB culture histopathology genotypic tests
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- 1.World Health Organization (WHO) (2010) Global tuberculosis control report, (Available from: http://www.int/tb/publications/global_report/2010/en/index.html)
- 3.Watts HG, Lifeso RM. (1996) Tuberculosis of bones and joints. J Bone Joint Surg (Am). 78: 288–98Google Scholar
- 5.API Consensus Expert Committee (2006) API TB consensus guidelines 2006: Management of pulmonary tuberculosis, extra pulmonary tuberculosis and tuberculosis special situations. J Assoc Physicians India 54: 219–234Google Scholar
- 8.The Global Laboratory Initiative (2010) A road map for ensuring quality tuberculosis diagnostic services within National Laboratory Strategic plans: prepared by the global laboratory initiative in advancing TB diagnostics. WHO, First issue 20th January 2010. (Available from: www.tbevidence.org/documents/rescentre/books/GLI_Roadmap_2010.pdf)
- 11.Strategic and Technical Advisory Group for TB (STAG-TB) Report of the 10th meeting 27th–29th Sep 2010.WHO/htm/tb/2010.18Google Scholar
- 14.World Health Organization (WHO) (2008) Policy statement: molecular Line Probe Assays for rapid screening of patients at risk of MDR tuberculosis — Strategic and Technical Advisory Group for TB (STAG-TB), 27th June 2008 (Available from: http://www.who.int/tb/features_archive/policy_statement.pdf)
- 16.Stop TB Partnership 2010, World Health Organization (WHO) (2010) The global plan to stop TB, 2011-2015 (Available from: http://www.stoptb.org/global/plan/)