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Economic Botany

, Volume 66, Issue 3, pp 298–310 | Cite as

The Ethnobotany and Ethnopharmacology of Wild Tomatillos, Physalis longifolia Nutt., and Related Physalis Species: A Review

  • Kelly Kindscher
  • Quinn Long
  • Steve Corbett
  • Kirsten Bosnak
  • Hillary Loring
  • Mark Cohen
  • Barbara N. Timmermann
Review

Abstract

The Ethnobotany and Ethnopharmacology of Wild Tomatillos, Physalis longifolia Nutt., and Related Physalis Species: A Review. The wild tomatillo, Physalis longifolia Nutt., and related species have been important wild-harvested foods and medicinal plants. This paper reviews their traditional use as food and medicine; it also discusses taxonomic difficulties and provides information on recent medicinal chemistry discoveries within this and related species. Subtle morphological differences recognized by taxonomists to distinguish this species from closely related taxa can be confusing to botanists and ethnobotanists, and many of these differences are not considered to be important by indigenous people. Therefore, the food and medicinal uses reported here include information for P. longifolia, as well as uses for several related taxa found north of Mexico. The importance of wild Physalis species as food is reported by many tribes, and its long history of use is evidenced by frequent discovery in archaeological sites. These plants may have been cultivated, or “tended,” by Pueblo farmers and other tribes. The importance of this plant as medicine is made evident through its historical ethnobotanical use, information in recent literature on Physalis species pharmacology, and our Native Medicinal Plant Research Program’s recent discovery of 14 new natural products, some of which have potent anti-cancer activity.

Keywords

Physalis longifolia Ethnobotany medicinal anti-cancer Tomatillos Paleoethnobotany traditional ecological knowledge Ethnopharmacology medicinal chemistry 

La Etnobotánica y Etnofarmacología de los Tomatillos Silvestres, Physalis longifolia Nutt., y Especies Afines a Physalis: Una Revisión

Resumen

La Etnobotánica y Etnofarmacología de los Tomatillos Silvestres, Physalis longifolia Nutt., y Especies Afines a Physalis: Una Revisión. El tomatillo silvestre, Physalis longifolia Nutt., y especies afines han sido un importante recurso de alimentos silvestres y de plantas medicinales. Revisamos los usos tradicionales para la alimentación y la medicina, las dificultades taxonómicas, y proporcionamos los últimos descubrimientos de la química medicinal de esta y de otras especies afines. Las sutiles diferencias morfológicas reconocidas por los taxónomos para poder distinguir las estrechas relaciones de taxones entre estas especies son confusas para los botánicos y los etnobotánicos, pero estas diferencias no son reconocidas como importantes por las poblaciones nativas. Por lo tanto, los usos alimenticios y medicinales reportados incluyen no sólo información sobre P. longifolia, sino también para varios taxones relacionados que se encuentran al norte de México. La importancia de las especies silvestres de Physalis como alimento es reportada por muchas tribus y su larga historia de uso se pone de manifiesto por el descubrimiento frecuente en yacimientos arqueológicos. Estas plantas pueden haber sido cultivadas o “atendidas” por los agricultores de Pueblos y otras tribus. La importancia de esta planta como medicina se destaca por su historia de uso etnobotánico, por la literatura reciente sobre la farmacología de las especies de Physalis y por el descubrimiento reciente en nuestro Programa Nativo de Investigación de Plantas Medicinales de 14 nuevos productos naturales, algunos de los cuales tienen potente actividad de anti-cáncer.

Notes

Acknowledgements

This study was supported by grant IND0061464 (awarded to B. Timmermann and K. Kindscher) from the Kansas Bioscience Authority and Heartland Plant Innovations. We have received help from many people with our work on Physalis. Craig Freeman of the R.L. McGregor Herbarium at the University of Kansas has been especially helpful with making species identification. Janet Sullivan of the Albion Hodgdon Herbarium at the University of New Hampshire reviewed the taxonomy in the paper. Maria Pontes Ferreira, Nutrition and Food Science Department, Wayne State University, and Jennifer Delisle, Kansas Biological Survey, helped us with field collections. Dana Peterson and Gorgina Ross (both of the Kansas Biological Survey), respectively, created the distribution map and wrote the Spanish abstract. Important reviews of the manuscript and valuable feedback were provided by Richard Felger, University of Arizona; Richard Ford, Anthropology Department, University of Michigan; and Pam McBride, New Mexico Office of Archeological Studies. Many other staff and students have been helpful in the field, lab, and gardens, including Juan Jose Araya Barrantes, Luanna Bailey, Greg Beverlin, Rachel Craft, Bryn Fragua, Robert Gallagher, Rao Gollapudi, Jason Hering, Tommy Leopard, Kim Scherman, Lauren Service, Ashley Stiffarm, Joe Stogsdill, Robbie Wood III, and Huaping Zhang.

Literature Cited

  1. Adair, M. J. and M. E. Brown. 1978. The Two Deer Site (14BU55): A Plains Woodland–Plains Village Transition. In Prehistory and History of the El Dorado Lake Area (Phase II). Project Report Series No. 47. Museum of Anthropology. University of Kansas. Lawrence.Google Scholar
  2. Adams, K. 2002. Archaeobotanical Studies and Paleoenvironmental Reconstructions, Gila River Indian Community, Arizona. P-MIP Technical Report No. 2002–03.Google Scholar
  3. Allred, K. 2010. Flora Neomexicana I: The vascular plants of New Mexico, an Annotated Checklist to the Names of Vascular Plants with Synonymy and Bibliography. Available: http://www.lulu.com/.
  4. Benn, D. W. 1974. Seed Analysis and Its Implications for an Initial Middle Missouri Site in South Dakota. Plains Anthropologist 19:55–72.Google Scholar
  5. Bohrer, V. 1991. Recently Recognized Cultivated and Encouraged Plants Among the Hohokam. Kiva 56:227–235.Google Scholar
  6. Brandt, Carol B. 1991. The River’s Edge Archaeobotanical Analysis: Patterns in Plant Refuse. Zuni Pueblo, New Mexico. Zuni Archaeology Program. Ethnobiological Technical Series 91-2.Google Scholar
  7. Burrows, G. E. and R. J. Tyrl. 2001. Toxic Plants of North America. Iowa State University Press, Ames.Google Scholar
  8. Cable, John, Lisa O’Steen, Leslie E. Raymer, Johannes H. N. Loubser, David S. Leigh, J. W. Joseph, Mary Beth Reed, Lotta Danielsson-Murphy, Undine McEvoy, Thaddeus Murphy, Mary Theresa Bonhage-Freund, and Deborah Wallsmith. 1997. A Picture Unsurpassed: Prehistoric and Historic Indian Settlement and Landscape, Brasstown Valley, Towns County, Georgia. Report on File at New South Associates, Georgia. Stone Mountain.Google Scholar
  9. Castetter, E. E. 1935. Uncultivated Native Plants Used as Food—Ethnobotanical Studies in the American Southwest. New Mexico University Biological Series Bulletin 4(1).Google Scholar
  10. Castetter, E. F. and M. E. Opler. 1936. The Ethnobiology of the Chiricahua and Mescalero Apache; Ethnobiological Studies in the American Southwest: III. A. The Use Of Plants For Foods, Beverages And Narcotics. University of New Mexico 4:3–63.Google Scholar
  11. Chen, L. X., H. Hao, and F. Qiu. 2011. Natural Withanolides: an Overview. Natural Products Reports 28:705–740.CrossRefGoogle Scholar
  12. Cozzo, D. N. 2004. Ethnobotanical Classification System and Medicinal Ethnobotany of the Eastern Band of the Cherokee Indians. Ph.D. Dissertation. Anthropology Department, University of Georgia.Google Scholar
  13. Crawford, G. W., and D. G. Smith. 2003. Paleoethnobotany in the Northeast. Pages 172-257. in P.E. Minnis, editor. People and Plants in Ancient Eastern North America. Smithsonian: Washington, D.C.Google Scholar
  14. Cushing, F. H. (1920). Zuni Breadstuff. Museum of the American Indian, Heye Foundation. New York.Google Scholar
  15. Dello-Russo, R. D. 1999. Climatic Stress in the Middle Rio Grande Valley of New Mexico: An Evaluation of Changes in Foraging Behaviors During the Late Archaic/Basketmaker II Period. Unpublished Ph.D. dissertation. University of New Mexico. Albuquerque.Google Scholar
  16. Dering, J. P. 1993a. Plant Remains. In Data Recovery at Justiceburg Reservoir (Lake Alan Henry), Garza, and Kent Counties, Texas: Phase III, Season 2, edited by D.K. Boyd. Prewitt and Associates, Austin, Texas, 431–434.Google Scholar
  17. Dering, J. P. 1993b. Plant Remains. Pages 431–434. in D.K. Boyd, editor. In Data Recovery at Justiceburg Reservoir (Lake Alan Henry), Garza, and Kent Counties, Texas: Phase III, Season 2. Prewitt and Associates, Texas. AustinGoogle Scholar
  18. Doebley, J. F. 1981. Plant Remains Recovered by Floatation from Trash at Salmon Ruin, New Mexico. Kiva 46:169–187.Google Scholar
  19. Drass, R. R. 1993. Macrobotanical Remains from Two Early Plains Village Sites in Central Oklahoma. Plains Anthropologist 38:51–64.Google Scholar
  20. Edaakie, R. 1999. Idonaphshe—Let’s Eat—Traditional Zuni Foods. A:shiwi A:wan Museum and Heritage Center, Zuni, New Mexico. Zuni.Google Scholar
  21. Eich, E. 2008. Solanaceae and Convolvulaceae: Secondary Metabolites. Spring-Verlag, Berlin.CrossRefGoogle Scholar
  22. Erowid 2011. From: http://www.erowid.org/psychoactives/law/states/states_info1.shtml. Accessed November 15, 2011.
  23. Fletcher, A. C. and F. LaFlesche. 1911. The Omaha Tribe. Smithsonian Institution. Bureau of American Ethnology 27:76–78.Google Scholar
  24. Fuller, T. and E. McClintock. 1986. Poisonous Plants of California. University of California Press, Berkeley.Google Scholar
  25. Gilmore, M. R. 1913. Some Native Nebraska Plants with Their Uses by the Dakota. Nebraska State Historical Society 17:358–371.Google Scholar
  26. Gilmore, M. R. 1977. Uses of Plants by the Indians of the Missouri River Region. University of Nebraska Press, Lincoln.Google Scholar
  27. Hamel, P. B. and M. U. Chiltoskey. 1975. Cherokee lants: Their Uses—a 400 Year History. Herald Publishing Company, North Carolina. Sylva.Google Scholar
  28. Hart, J. A. 1981. The Ethnobotany of the Northern Cheyenne Indians of Montana. Journal of Ethnopharmacology 4:1–55.PubMedCrossRefGoogle Scholar
  29. Herrick, J. W. 1995. Iroquois Medical Botany. Syracuse University Press, New York. Syracuse.Google Scholar
  30. Hough, W. 1898. Environmental Interrelations in Arizona. American Anthropologist 11(5):133–155.CrossRefGoogle Scholar
  31. Hsu, C., Y. Wua, L. Farh, Y. Dua, W. Tseng, C. Wuf, and F. Chang. 2012. Physalin B from Physalis angulata Triggers the NOXA-related Apoptosis Pathway of Human Melanoma A375 cells. Food and Chemical Toxicology 50:619–624.PubMedCrossRefGoogle Scholar
  32. Hsua, Y., C. Wub, H. Changc, K. Kumara, M. Linb, C. Cheni, H. Choi, C. Huangi, C. Huangd, H. Leee, W. Hsiehf, J. Chungg, H. Wangh, and H. Yangi. 2011. Inhibitory effects of Physalis angulata on tumor metastasis and angiogenesis. Journal of Ethnopharmacology 135:762–771.CrossRefGoogle Scholar
  33. Invasive Plant Atlas of the United States. 2011. From: http://www.invasive.org, Accessed July 31, 2011.
  34. Jin, Z., M. Mashuta, N. Stolowich, A. Vaisberg, N. Stivers, P. Bates, W. Lewis, and G. Hammond. 2012. Physangulidines A, B, and C: Three New Antiproliferative Withanolides from Physalis angulata L. Organic Letters 14:1230–1233.PubMedCrossRefGoogle Scholar
  35. Kindscher, K. and D. P. Hurlburt. 1998. Huron Smith’s Ethnobotany of the Hocąk (Winnebago). Economic Botany 52(4):352–372.CrossRefGoogle Scholar
  36. Kuckelman, Kristin A., editor. 2003. The Archaeology of Yellow Jacket Pueblo (Site 5MT5): Excavations at a Large Community Center in Southwestern Colorado. Crow Canyon Archaeological Center, Colorado. Cortez.Google Scholar
  37. Laferriere, J. E., C. W. Weber, and E. A. Kohlhepp. 1991. Use and Nutritional Composition of Some Traditional Mountain Pima Plant Foods. Journal of Ethnobiology 11:93–114.Google Scholar
  38. Lavie, D., E. Glotter, and Y. Shvo. 1965. Constituents of Withania somnifera Dun. III. The Side Chain of Withaferin A. Journal of Organic Chemistry 30:1774–1778.CrossRefGoogle Scholar
  39. Lee, C. and P. Houghton. 2005. Cytotoxicity of Plants from Malaysia and Thailand used Traditionally to Treat Cancer. Journal of Ethnopharmacology 100:237–243.PubMedCrossRefGoogle Scholar
  40. Leong, O., T. Muhammad, and S. Sulaiman. 2011. Cytotoxic Activities of Physalis minima L. Chloroform Extract on Human Lung Adenocarcinoma NCI-H23 Cell Lines by Induction of Apoptosis. Evidence-based Complementary and Alternative Medicine. doi: 10.1093/ecam/nep057.
  41. Louisiana State Act 159. 2006. From: http://www.legis.state.la.us/billdata/streamdocument.asp?did=288583. Accessed August 15, 2011.
  42. McBride, Pamela J. 2008. Diet and Subsistence on the Pajarito Plateau: Evidence from Flotation and Vegetal Sample Analysis. In The Land Conveyance and Transfer Data Recovery Project: 7000 Years of Land Use on the Pajarito Plateau, Volume 3: Artifact and Sample. Analyses, edited by Bradley J. Vierra and Kari M. Schmidt, pp. 399–521. Los Alamos National Laboratory, Cultural Resources Report No. 273. New Mexico. Los Alamos.Google Scholar
  43. McBride, Pamela J. and Susan J. Smith. 2011. Agua Fria Schoolhouse Archaeobotanical Record. Manuscript on file, Southwest Archaeological Consultants, Santa Fe, New Mexico.Google Scholar
  44. Mead, B. 1981. Seed Analysis of the Meehan-Schell Site (13BN110), a great Oasis Site in Central Iowa. Journal of the Iowa Archeological Society 28:15–90.Google Scholar
  45. Minnis, P. E. 1989. Prehistoric Diet In The Northern Southwest: Macroplant Remains From Four Corners Feces. American Antiquity 54(3):543–563.CrossRefGoogle Scholar
  46. Minnis, P. E. 2001. One Possible Future of Ethnobiology. in R. Ford, editor. In Ethnobiology at the Millenium—Past Promise and Future Prospects. Museum of Anthropology. University of Michigan. Athropological Papers, Number 91.Google Scholar
  47. Mishra, L., B. B. Singh, and S. Dagenais. 2000. Scientific Basis for the Therapeutic Use of Withania somnifera (Ashwagandha): A Review. Alternative Medicine Review 5:334–346.PubMedGoogle Scholar
  48. Misico, R. I., V. E. Nicotra, J. C. Oberti, G. Barboza, R. R. Gil, and G. Burton. 2011. Withanolides and Related Steroids. Progress in the Chemical of Organic Natural Products 94:127–229.CrossRefGoogle Scholar
  49. Moerman, D. 2011. Native American Ethnobotany, http://herb.umd.umich.edu/. Accessed November 11, 2011.
  50. Monograph. 2004. Withania somnifera. Alternative Medicine Review 9:211–214.Google Scholar
  51. Nabhan, G. 1985. Native Crop Diversity in Aridoamerica: Conservation of Regional Gene Pools. Economic Botany 39:387–399.CrossRefGoogle Scholar
  52. Nabhan, G. 2008. Renewing America’s Food Traditions: Saving and Savoring the Continent’s Most Endangered Foods. Chelsea Green Publishing Company, Vermont. White River Junction.Google Scholar
  53. Nickel, R. K. 1974. Plant Resource Utilization at a Late Prehistoric Site in North-central South Dakota. Master’s thesis, Department of Anthropology. University of Nebraska.Google Scholar
  54. Peterson, L. E. 1977. A Field Guide to Edible Wild Plants: Eastern and Central North America. Houghton Mifflin Company, New York.Google Scholar
  55. Puente, L. A., C. A. Pinto-Munoz, E. S. Castro, and M. Cortes. 2011. Physalis peruviana L., the Multiple Properties of a Highly Functional Fruit: a Review. Food Research International 44:1733–1740.CrossRefGoogle Scholar
  56. Rea, A. M. 1997. At the Desert’s Green Edge: An Ethnobotany of the Gila River Pima. University of Arizona Press, Tucson.Google Scholar
  57. Rogers, D. J. 1980. Lakota Names and Traditional Uses of Native Plants by Sicangu (Brule) People in the Rosebud Area, South Dakota. The Rosebud Educational Society, Inc, St. Francis.Google Scholar
  58. Samadi, A. K., X. Q. Tong, R. Mukerji, H. P. Zhang, B. N. Timmermann, and M. S. Cohen. 2010. Withaferin A, a Cytotoxic Steroid from Vassobia breviflora, Induces Apoptosis in Human Head and Neck Squamous Cell Carcinoma. Journal of Natural Products 73:1476–1481.PubMedCrossRefGoogle Scholar
  59. Scarry, C. M. 2003. Patterns of Wild Plant Utilization in the Prehistoric Eastern Woodlands. In People and Plants in Ancient Eastern North America. Smithsonian, Washington, DC: 50–104.Google Scholar
  60. Schultes, R. E. 1970. The Plant Kingdom and Hallucinogens (part 3). Bulletin on Narcotics 22:25–53.Google Scholar
  61. Smith, H. H. 1928. Ethnobotany of the Meskwaki Indians. Bulletin of the Public Museum of the City of Milwaukee 4(2):175–326.Google Scholar
  62. Stevenson, M. C. 1915. Ethnobotany of the Zuni Indians: Medical Practices and Medicinal Plants. Thirtieth Annual Report of the Bureau of American Ethnology 30:39–64.Google Scholar
  63. Sullivan, J. R. 1984. Pollination Biology of Physalis viscosa var. cinerascens (Solanaceae). American Journal of Botany 71:815–820.CrossRefGoogle Scholar
  64. Toll, Mollie S., and Pamela J. McBride. 2011. Flotation Remains from Prehistoric Proveniences. Ch. 13 in Archaeological Excavations at El Pueblo de Santa Fe (LA 1051). Volume 1: Village of the Shell Bead Water People: A Prehistoric Trade and Ceremonial Community in Downtown Santa Fe, New Mexico, by Stephen C. Lentz, Archaeology Notes 410. Museum of New Mexico, Office of Archaeological Studies. Santa Fe.Google Scholar
  65. USDA, NRCS. 2011. The PLANTS Database (http://plants.usda.gov, 16 August 2011). National Plant Data Team, Greensboro, North Carolina 27401-4901 USA.
  66. VanDerwarker, Amber. 2012. personal communication.Google Scholar
  67. Veleiro, A. S., J. C. Oberti, and G. Burton. 2005. Chemistry and Bioactivity of Withanolides from South American Solanaceae. in Atta-ur-Rahman, editor. Studies in Natural Products Chemistry. Elsevier Science, B.V.: Amsterdam, Vol. 32:1019–1051.Google Scholar
  68. Vestal, P. A. 1952. Ethnobotany of the Ramah Navaho. Papers of the Peabody Museum of American Archaeology and Ethnology. Harvard University Reports of the Ramah Project, vol 40, number 4.Google Scholar
  69. Von Mueller, B. F. 1895. Select Extra-Tropical Plants, Readily Eligible for Industrial, Culture or Naturalisation. Robert Drain, Government Printer, Melbourne, Australia.Google Scholar
  70. Wetterstrom, W. 1986. Food, Diet, and Population at Prehistoric Arroyo Hondo Pueblo, New Mexico. School of American Research Press, Santa Fe.Google Scholar
  71. Whitson, M. 2011. (2016) Proposal to Conserve the Name Physalis (Solanaceae) with a conserved type. Taxon 60:608–609.Google Scholar
  72. Whitson, M., and P. S. Manos. 2005. Untangling Physalis (Solanaceae) from the Physaloids: A Two-Gene Phylogeny of the Physalinae. Systematic Botany 30(1):216–230.CrossRefGoogle Scholar
  73. Wikipedia. 2011. From: http://en.wikipedia.org/wiki/Physalis. Accessed August 15, 2011.
  74. Yanovsky, E. 1936. Food Plants of the North American Indians. United States Department of Agriculture Miscellaneous Publication 237:1–83.Google Scholar
  75. Yarnell, R. A. 1965. Implications of Distinctive Flora on Pueblo Ruins. American Anthropologist 67(3):662–674.CrossRefGoogle Scholar
  76. Zhang, H., A. K. Samadi, R. J. Gallagher, J. J. Araya, X. Tong, V. W. Day, M. S. Cohen, K. Kindscher, R. Gollapudi, and B. N. Timmermann. 2011. Cytotoxic Withanolide Constituents of Physalis longifolia. Journal of Natural Products. 74:2532–2544.PubMedCrossRefGoogle Scholar
  77. Zhang, H., A. K. Samadi, M. S. Cohen, and B. N. Timmermann. 2012. Antiproliferative Withanolides from the Solanaceae: A Structure-activity Study. Pure Applied Chemistry 84(6):1353–1367.CrossRefGoogle Scholar
  78. Zier, C. J. and S. M. Kalasz. 1991. Recon John Shelter and the Archaic-Woodland Transition in Southeastern Colorado. Plains Anthropologist 36:111–138.Google Scholar

Copyright information

© The New York Botanical Garden 2012

Authors and Affiliations

  • Kelly Kindscher
    • 1
  • Quinn Long
    • 2
  • Steve Corbett
    • 1
  • Kirsten Bosnak
    • 1
  • Hillary Loring
    • 1
  • Mark Cohen
    • 3
  • Barbara N. Timmermann
    • 4
  1. 1.Kansas Biological SurveyUniversity of KansasLawrenceUSA
  2. 2.Missouri Botanical GardenSt. LouisUSA
  3. 3.Department of SurgeryUniversity of Kansas Medical CenterKansas CityUSA
  4. 4.Department of Medicinal ChemistryUniversity of KansasLawrenceUSA

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