Two SAPP2 gene homologs are present in Candida parapsilosis genome
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Candida parapsilosis produces secreted aspartic proteinases (Saps), which contribute to the virulence of this opportunistic pathogen. Gene family containing as many as 14 sequences potentially encoding secreted aspartic proteinases was identified in C. parapsilosis genome. Of them, SAPP1 and SAPP2 genes have been extensively characterized, but only now do we report that two SAPP2 homologs sharing 91.5 % identity occur in C. parapsilosis genome. Existence of SAPP2 homologs points to unexpected complexity of the SAPP gene family.
KeywordsPeptide Substrate Aspartic Proteinase Acid Proteinase Candida Parapsilosis Fluorogenic Peptide
This work was supported by grants GA14-23022S from the Czech Science Foundation and by project LO1302 (NPU I, LO) from Ministry of Education of the Czech Republic, and RVO 61388963 project.