Folia Microbiologica

, Volume 60, Issue 5, pp 373–374 | Cite as

Two SAPP2 gene homologs are present in Candida parapsilosis genome

  • Jiří Dostál
  • Michaela Merkerová
  • Zuzana Vinterová
  • Iva Pichová
  • Olga Hrušková-HeidingsfeldováEmail author


Candida parapsilosis produces secreted aspartic proteinases (Saps), which contribute to the virulence of this opportunistic pathogen. Gene family containing as many as 14 sequences potentially encoding secreted aspartic proteinases was identified in C. parapsilosis genome. Of them, SAPP1 and SAPP2 genes have been extensively characterized, but only now do we report that two SAPP2 homologs sharing 91.5 % identity occur in C. parapsilosis genome. Existence of SAPP2 homologs points to unexpected complexity of the SAPP gene family.


Peptide Substrate Aspartic Proteinase Acid Proteinase Candida Parapsilosis Fluorogenic Peptide 
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This work was supported by grants GA14-23022S from the Czech Science Foundation and by project LO1302 (NPU I, LO) from Ministry of Education of the Czech Republic, and RVO 61388963 project.


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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i. 2014

Authors and Affiliations

  • Jiří Dostál
    • 1
  • Michaela Merkerová
    • 1
    • 2
  • Zuzana Vinterová
    • 1
  • Iva Pichová
    • 1
  • Olga Hrušková-Heidingsfeldová
    • 1
    Email author
  1. 1.Institute of Organic Chemistry and BiochemistryAcademy of Sciences of the Czech RepublicPragueCzech Republic
  2. 2.Institute of Hematology and Blood TransfusionPragueCzech Republic

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