Folia Microbiologica

, Volume 60, Issue 1, pp 69–80 | Cite as

The oral microbiome diversity and its relation to human diseases

  • Jinzhi He
  • Yan Li
  • Yangpei Cao
  • Jin Xue
  • Xuedong ZhouEmail author


As one of the most clinically relevant human habitats, the human mouth is colonized by a set of microorganisms, including bacteria, archaea, fungi, and viruses. Increasing evidence has supported that these microbiota contribute to the two commonest oral diseases of man (dental caries and periodontal diseases), presenting significant risk factors to human health conditions, such as tumor, diabetes mellitus, cardiovascular diseases, bacteremia, preterm birth, and low birth weight in infants. It is widely accepted that oral microorganisms cause diseases mainly by a synergistic or cooperative way, and the interspecies interactions within the oral community play a crucial role in determining whether oral microbiota elicit diseases or not. Since a comprehensive understanding of the complex interspecies interactions within a community needs the knowledge of its endogenous residents, a plenty of research have been carried out to explore the oral microbial diversity. In this review, we focus on the recent progress in this field, including the oral microbiome composition and its association with human diseases.


Periodontitis Oral Squamous Cell Carcinoma Dental Caries Root Canal Oral Squamous Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by the International Science and Technology Cooperation Program of China (grant number 2011DFA30940), the National Basic Research Program of China (“973 Pilot Research Program,” grant number 2011CB512108), project supported by the National Natural Science Foundation of China (grant numbers 30901689 and 81172579), and Sichuan Provincial Department of Science and Technology project (2013SZ0039).

Conflict of interests

The authors declare that they have no conflict of interest.


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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i. 2014

Authors and Affiliations

  • Jinzhi He
    • 1
    • 2
  • Yan Li
    • 1
  • Yangpei Cao
    • 1
    • 2
  • Jin Xue
    • 1
    • 2
  • Xuedong Zhou
    • 1
    • 2
    Email author
  1. 1.State Key Laboratory of Oral Diseases, West China Hospital of StomatologySichuan UniversityChengduChina
  2. 2.Department of Endodontics and Operative DentistryWest China Hospital of StomatologyChengduChina

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