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Folia Microbiologica

, Volume 55, Issue 2, pp 176–180 | Cite as

Interactions of antibiotics and extracts of Helichrysum pedunculatum against bacteria implicated in wound infections

  • O. A. Aiyegoro
  • A. J. Afolayan
  • A. I. OkohEmail author
Article

Abstract

The effect of combinations of the crude acetone and aqueous extracts of Helichrysum pedunculatum leaves and eight antibiotics was determined by means of checkerboard and time-kill methods. In the checkerboard method, synergy of 45.8 % was observed, being independent of Gram reaction, with combinations in the aqueous extract yielding largely (18.8 %) antagonistic interactions. The time-kill assay detected synergy (45.8 %) that was also independent of Gram reaction with a potentiation of more than 3 orders of the bactericidal activity of the test antibiotics. The crude leaf extracts of H. pedunculatum could thus be considered to be potential source of a broad-spectrum antibiotic-resistance-modifying compounds.

Keywords

Gatifloxacin EUCAST Fractional Inhibitory Concentration Fractional Inhibitory Concentration Index Crude Leaf Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

FIC

fractional inhibitory concentration

MDR

multi drug resistance

MIC

minimum inhibitory concentration

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Copyright information

© Institute of Microbiology, v.v.i, Academy of Sciences of the Czech Republic 2010

Authors and Affiliations

  1. 1.Department of Biochemistry and MicrobiologyUniversity of Fort HareAliceSouth Africa
  2. 2.Department of BotanyUniversity of Fort HareAliceSouth Africa

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