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Fibers and Polymers

, Volume 19, Issue 7, pp 1454–1462 | Cite as

Mucoadhesive Chitosan Electrospun Nanofibers Containing Tetracycline and Triamcinolone as a Drug Delivery System

  • Leila Behbood
  • Soroush Karimi
  • Esmaeil Mirzaei
  • Ghobad Mohammadi
  • Mahsa Azami
  • Elham Arkan
Article
  • 36 Downloads

Abstract

The mucoadhesive Chitosan (CS) nanofibers as a drug delivery system were developed. Chitosan was modified via the immobilization of thiol groups from L-cysteine as a mucoadhesive reagent. The mucoadhesive properties of the chitosan nanofibers were evaluated by tensiometer set and via tensile studies. Drug and mucoadhesive agent loading lead to decrease diameters and increased porous of nanofibers. The release of Tetracycline (Tet) and Triamcinolone (Tri) were increased with increasing immersion time and it became constant at long immersion times. Mucoadhesion studies were done at pH 2–7 and in pH 6 maximum mucoadhesive properties observed. Release studies demonstrated a sustained release of both drug continued up to 48 hours. Microbial studies were performed on the nanofibers. The drug delivery system represented a novel tool for improve the therapeutic efficacy of various drugs that are poorly absorbed from the gastrointestinal tract. Also it is an efficient system for treatment of oral ulceration.

Keywords

Chitosan Electrospun nanofibers Mucoadhesive Drug delivery 

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Copyright information

© The Korean Fiber Society and Springer Nature B.V. 2018

Authors and Affiliations

  • Leila Behbood
    • 1
  • Soroush Karimi
    • 2
  • Esmaeil Mirzaei
    • 3
  • Ghobad Mohammadi
    • 1
  • Mahsa Azami
    • 4
  • Elham Arkan
    • 2
  1. 1.Pharmaceutical Sciences Research CenterKermanshah University of Medical SciencesKermanshahIran
  2. 2.Nano Drug Delivery Research CenterKermanshah University of Medical SciencesKermanshahIran
  3. 3.Department of Medical Nanotechnology, School of Advanced Medical Sciences and TechnologiesShiraz University of Medical SciencesShirazIran
  4. 4.Department of Pharmaceutics, School of PharmacyKermanshah University of Medical SciencesKermanshahIran

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