Fibers and Polymers

, Volume 18, Issue 5, pp 922–932 | Cite as

Electrospinning of fucoidan/chitosan/poly(vinyl alcohol) scaffolds for vascular tissue engineering

  • Weijie Zhang
  • Lei Zhao
  • Jianzhong Ma
  • Xiaochun Wang
  • Yonggang Wang
  • Fen Ran
  • Yanling Wang
  • Hui Ma
  • Shujing Yu
Article
First Online:
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Revised:
Accepted:

Abstract

The formation of thrombosis has limited the applications of small diameter vascular in cardiovascular diseases. In order to improve the anticoagulant activities of scaffolds, this study combined fucoidan with CS/PVA and investigated the complete physicochemical and mechanical characterization of the scaffolds to evaluate the feasibility of Fucoidan/CS/PVA scaffolds used in vascular tissue engineering. The SEM graphs show a well defined and interconnected pore structure and the nanofiber diameters are ranging from 341 nm to 482 nm. After immersing in PBS for 5 days, the tensile strength of the crosslinked scaffolds was 722±38 kPa while the elongation at break was 35.5±1.6 %. Besides, added with fucoidan, the scafflolds showed lower rate of plate adhesion (14.75±2.10 %) and markedly prolonged the APTT and TT. Furthermore, owing to the great water uptake ability, sufficient porosity, enhanced drug release and low cytotoxicity, the Fucoidan/CS/PVA scaffolds might be used for vascular tissue engineering with good prospect.

Keywords

Fucoidan Electrospinning Hemocompatibility Vascular tissue engineering 
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Copyright information

© The Korean Fiber Society and Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  • Weijie Zhang
    • 1
  • Lei Zhao
    • 1
  • Jianzhong Ma
    • 1
  • Xiaochun Wang
    • 1
  • Yonggang Wang
    • 1
  • Fen Ran
    • 2
  • Yanling Wang
    • 1
  • Hui Ma
    • 1
  • Shujing Yu
    • 3
  1. 1.School of Life Science and EngineeringLanzhou University of TechnologyLanzhou, GansuChina
  2. 2.School of Materials Science and EngineeringLanzhou University of TechnologyLanzhou, GansuChina
  3. 3.Pathology DepartmentWuqiang County HospitalWuqiang County, HebeiChina

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