An experimental study of a spring-loaded needle-free injector: Influence of the ejection volume and injector orifice diameter
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Needle-free injection is an alternative strategy to conventional needle injection in the field of drug delivery. This approach offers a number of advantages, especially in reducing complaints of needle phobia and avoiding the occurrence of accidental needle stick injuries. The ejection volume and orifice diameter are inherently important in determining the injection depth and percent delivery. In this study, we investigate the dispersion pattern of liquid penetration into gels and porcine tissues using a needle-free injector with ejection volumes of 0.05 to 0.35 mL and orifice diameters of 0.17 to 0.50 mm. In addition, the influence of the two parameters is analyzed quantitatively on the dispersion pattern through impact experiments and injection experiments. Furthermore, an equation of the jet power calculated by the ejection volume and orifice diameter is proposed to describe the delivery fraction of the injection experiments. Controls of the ejection volume and orifice diameter are demonstrated to help achieve a more effective injection process and a better injection experience.
KeywordsBiomedical devices Fluid dispersion Jet penetration Jet power Needle-free injection Transdermal drug delivery
The area of the nozzle exit section
Jet power at the nozzle exit
The total depth of the dispersion
The distance from the surface to the location of maximum width of the dispersion region
The distance of the injection region
The maximum width of the dispersion region
The width of the injection region
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This work was supported by the National Key Basic Research Program of China (grant number: 2014CB239203); the National Natural Science Foundation of China (NSFC) (grant number: 51474158); and the Natural Science Foundation of Hubei Province of China (Key Program) (grant number: 2016CFA088).
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