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Journal of Mechanical Science and Technology

, Volume 33, Issue 11, pp 5581–5588 | Cite as

An experimental study of a spring-loaded needle-free injector: Influence of the ejection volume and injector orifice diameter

  • Dongping Zeng
  • Ni Wu
  • Lu Xie
  • Xiaoxiao Xia
  • Yong KangEmail author
Article
  • 13 Downloads

Abstract

Needle-free injection is an alternative strategy to conventional needle injection in the field of drug delivery. This approach offers a number of advantages, especially in reducing complaints of needle phobia and avoiding the occurrence of accidental needle stick injuries. The ejection volume and orifice diameter are inherently important in determining the injection depth and percent delivery. In this study, we investigate the dispersion pattern of liquid penetration into gels and porcine tissues using a needle-free injector with ejection volumes of 0.05 to 0.35 mL and orifice diameters of 0.17 to 0.50 mm. In addition, the influence of the two parameters is analyzed quantitatively on the dispersion pattern through impact experiments and injection experiments. Furthermore, an equation of the jet power calculated by the ejection volume and orifice diameter is proposed to describe the delivery fraction of the injection experiments. Controls of the ejection volume and orifice diameter are demonstrated to help achieve a more effective injection process and a better injection experience.

Keywords

Biomedical devices Fluid dispersion Jet penetration Jet power Needle-free injection Transdermal drug delivery 

Nomenclature

NFI

Needle-free injection

A0

The area of the nozzle exit section

D0

Orifice diameter

E0

Jet power at the nozzle exit

Lc

The total depth of the dispersion

Lm

The distance from the surface to the location of maximum width of the dispersion region

Ls

The distance of the injection region

Wk

The maximum width of the dispersion region

Wc

The width of the injection region

Q

Volume flowrate

T

Injection duration

ν0

Average velocity

ρ

Liquid density

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Notes

Acknowledgements

This work was supported by the National Key Basic Research Program of China (grant number: 2014CB239203); the National Natural Science Foundation of China (NSFC) (grant number: 51474158); and the Natural Science Foundation of Hubei Province of China (Key Program) (grant number: 2016CFA088).

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Copyright information

© KSME & Springer 2019

Authors and Affiliations

  • Dongping Zeng
    • 1
    • 2
    • 3
  • Ni Wu
    • 1
    • 2
    • 3
  • Lu Xie
    • 1
    • 2
    • 3
  • Xiaoxiao Xia
    • 1
    • 2
    • 3
  • Yong Kang
    • 1
    • 2
    • 3
    Email author
  1. 1.School of Power and Mechanical EngineeringWuhan UniversityWuhanChina
  2. 2.Hubei Key Laboratory of Accoutrement Technique in Fluid Machinery and Power EngineeringWuhan UniversityWuhanChina
  3. 3.Hubei Key Laboratory of Waterjet Theory and New TechnologyWuhan UniversityWuhanChina

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