Journal of Shanghai Jiaotong University (Science)

, Volume 19, Issue 6, pp 651–662 | Cite as

Sirtuin functions in the brain: From physiological to pathological aspects

  • Jia-xiang Shao (邵家骧)
  • Ting-ting Zhang (张婷婷)
  • Teng-yuan Liu (刘腾远)
  • Yi-zhou Quan (全亦周)
  • Fan Li (李 凡)
  • Jie Liu (刘 杰)
  • Xiao Yang (杨 霄)
  • Qian Xie (谢 谦)
  • Wei-liang Xia (夏伟梁)


Sirtuins are a family of nicotinamide adenine dinucleotide (NAD+) dependent deacetylases involved in multiple biological functions including metabolism, inflammation, stress resistance and aging. In mammals, there are seven members (Sirt1—Sirt7), with diversities in their subcellular localizations and enzymatic activities. Here, we review the functions of sirtuins, with a focus on their roles in normal brain physiology such as neural development regulation, body homeostasis maintenance, and memory formation. We also discuss the role of sirtuins in a variety of brain diseases including stroke, Alzheimer’s, Parkinson’s, and motor neuron dysfunction. Because of the emerging functions of sirtuins in brain physiology and pathology, drugs targeting sirtuins may offer potential therapeutic values for brain disorders.

Key words

sirtuin neural development hypothalamic function stroke neurodegeneration 

CLC number

Q 189 


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Copyright information

© Shanghai Jiaotong University and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Jia-xiang Shao (邵家骧)
    • 1
    • 2
    • 3
  • Ting-ting Zhang (张婷婷)
    • 2
    • 3
  • Teng-yuan Liu (刘腾远)
    • 2
    • 3
  • Yi-zhou Quan (全亦周)
    • 1
    • 2
    • 3
  • Fan Li (李 凡)
    • 2
    • 3
  • Jie Liu (刘 杰)
    • 1
    • 2
    • 3
  • Xiao Yang (杨 霄)
    • 2
    • 3
  • Qian Xie (谢 谦)
    • 2
    • 3
  • Wei-liang Xia (夏伟梁)
    • 1
    • 2
    • 3
  1. 1.State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina
  2. 2.School of Biomedical EngineeringShanghai Jiaotong UniversityShanghaiChina
  3. 3.Med-X Research InstituteShanghai Jiaotong UniversityShanghaiChina

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