Environmental Health and Preventive Medicine

, Volume 21, Issue 6, pp 554–562 | Cite as

Sasa veitchii extract suppresses carbon tetrachloride-induced hepato- and nephrotoxicity in mice

Regular Article

Abstract

Objective

The aim of this study was to investigate the therapeutic effects of a Sasa veitchii leaf extract (SE) on carbon tetrachloride (CCl4)-induced hepato- and nephrotoxicity.

Methods

Seven-week-old male ddy mice were orally administered SE or saline for seven days. Twenty-four hours after the last SE or saline administration, the mice were intraperitoneally injected with 3 g/kg CCl4 or olive oil. The mice from each group were euthanized and bled for plasma analysis 24 h after the CCl4/olive oil injection.

Results

We found that pretreatment with SE completely abolished the CCl4-induced mortality in the mice after 24 h. The mice pretreated with SE exhibited significantly decreased levels of functional markers, and reduced histological damage in both the liver and the kidney. Furthermore, we found that the SE pretreatment decreased lipid peroxidation and calcium levels in the liver. Although SE could not induce the free radical-scavenging metallothioneins, the plasma biological antioxidant power was significantly increased in the mice pretreated with SE.

Conclusion

Our findings demonstrate that prophylactic treatment with SE protects mice from CCl4-induced lethal toxicity by decreasing oxidative stress in the liver and kidney, presumably by increasing biological antioxidant power.

Keywords

Carbon tetrachloride Sasa veitchii Antioxidant Liver Kidney 

Notes

Acknowledgments

We thank Dr. Haruki Usuda (Shimane University, Japan) for his kind suggestions. We are grateful to Sunchlon Co., Ltd. for providing the compositional the data for SE.

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest.

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Copyright information

© The Japanese Society for Hygiene 2016

Authors and Affiliations

  1. 1.College of PharmacyKinjo Gakuin UniversityNagoyaJapan

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