Environmental Health and Preventive Medicine

, Volume 17, Issue 3, pp 191–198

Risk factors associated with disease progression and mortality in chronic kidney disease of uncertain etiology: a cohort study in Medawachchiya, Sri Lanka

  • Lalantha Senevirathna
  • Tilak Abeysekera
  • Shanika Nanayakkara
  • Rohana Chandrajith
  • Neelakanthi Ratnatunga
  • Kouji H. Harada
  • Toshiaki Hitomi
  • Toshiyuki Komiya
  • Eri Muso
  • Akio Koizumi
Regular Article

Abstract

Background

The alarming rise in the prevalence of chronic kidney disease of uncertain etiology (CKDu) among the low socioeconomic farming community in the North Central Province of Sri Lanka has been recognized as an emerging public health issue in the country.

Methods

This study sought to determine the possible factors associated with the progression and mortality of CKDu. The study utilized a single-center cohort registered in 2003 and followed up until 2009 in a regional clinic in the endemic region, and used a Cox proportional hazards model.

Results

We repeatedly found an association between disease progression and hypertension. Men were at higher risk of CKDu than women. A significant proportion of the patients in this cohort were underweight, which emphasized the need for future studies on the nutritional status of these patients.

Conclusions

Compared with findings in western countries and other regions of Asia, we identified hypertension as a major risk factor for progression of CKDu in this cohort.

Keywords

Chronic kidney disease of uncertain etiology Progression Hypertension Sri Lanka 

Supplementary material

12199_2011_237_MOESM1_ESM.pdf (77 kb)
Supplementary material 1 (PDF 77 kb)

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Copyright information

© The Japanese Society for Hygiene 2011

Authors and Affiliations

  • Lalantha Senevirathna
    • 1
  • Tilak Abeysekera
    • 2
  • Shanika Nanayakkara
    • 1
  • Rohana Chandrajith
    • 3
  • Neelakanthi Ratnatunga
    • 4
  • Kouji H. Harada
    • 1
  • Toshiaki Hitomi
    • 1
  • Toshiyuki Komiya
    • 5
  • Eri Muso
    • 5
  • Akio Koizumi
    • 1
  1. 1.Department of Health and Environmental SciencesKyoto University Graduate School of MedicineKyotoJapan
  2. 2.Nephrology UnitGeneral Hospital (Teaching)KandySri Lanka
  3. 3.Department of Geology, Faculty of ScienceUniversity of PeradeniyaPeradeniyaSri Lanka
  4. 4.Department of Pathology, Faculty of MedicineUniversity of PeradeniyaPeradeniyaSri Lanka
  5. 5.Department of Nephrology and DialysisKitano Hospital, Tazuke Kofukai Medical Research InstituteOsakaJapan

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