Environmental Health and Preventive Medicine

, Volume 16, Issue 4, pp 217–223

Brachial-ankle pulse wave velocity is an independent predictor of incident hypertension in Japanese normotensive male subjects

  • Hiroki Satoh
  • Yasuaki Saijo
  • Reiko Kishi
  • Hiroyuki Tsutsui
Regular Article

Abstract

Objectives

Cardiovascular morbidity and mortality are closely associated with hypertension, however, predictors of incident hypertension have not been fully established. We have conducted a study aimed at evaluating whether brachial-ankle pulse wave velocity (baPWV) is a predictor of incident hypertension.

Methods

The relation between baPWV, a noninvasive index of aortic stiffness, and incident hypertension was evaluated in a cohort of 2,278 Japanese normotensive male subjects with a follow-up of 3 years.

Results

Of the 2, 278 study participants, 151 (6.6%) had incident hypertension during the follow-up. After adjustment for variables, including age, gender, body mass index (BMI), smoking habit, alcohol consumption, diabetes mellitus, hyperlipidemia, family history of hypertension, heart rate, systolic blood pressure, low-density lipoprotein cholesterol, triglyceride, and fasting plasma glucose, multiple logistic regression analysis revealed that baPWV was a significant and independent predictor of incident hypertension with an adjusted odds ratio 1.45 (95% confidence interval 1.17–1.79, P < 0.01). In addition, baPWV values >1,380 cm/s indicated a high risk for incident hypertension.

Conclusions

Among the Japanese normotensive male subjects participating in this study, BaPWV was a significant and independent predictor of incident hypertension. This result suggests that BaPWV could be a useful screening method to identify normotensive individuals who should be targeted for interventions aimed at preventing the incident hypertension.

Keywords

Arterial stiffness Hypertension Pulse wave velocity Cohort studies Japanese male subjects 

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Copyright information

© The Japanese Society for Hygiene 2010

Authors and Affiliations

  • Hiroki Satoh
    • 1
    • 2
  • Yasuaki Saijo
    • 3
  • Reiko Kishi
    • 2
  • Hiroyuki Tsutsui
    • 1
  1. 1.Department of Cardiovascular MedicineHokkaido University Graduate School of MedicineSapporoJapan
  2. 2.Department of Public Health ScienceHokkaido University Graduate School of Medicine, Kita-kuSapporoJapan
  3. 3.Department of Health ScienceAsahikawa Medical CollegeAsahikawaJapan

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