Environmental Health and Preventive Medicine

, Volume 16, Issue 3, pp 139–143

Promoting effects of nanoparticles/materials on sensitive lung inflammatory diseases


DOI: 10.1007/s12199-010-0177-7

Cite this article as:
Inoue, K. Environ Health Prev Med (2011) 16: 139. doi:10.1007/s12199-010-0177-7


Although the adverse health effects of nanoparticles/materials have been proposed and are being clarified, their facilitating effects on preexisting pathological conditions have not been fully established. We provide insights into the environmental immunotoxicity of nanoparticles as an aggravating factor in hypersusceptible subjects, especially those with respiratory disorders, using our in vivo models. We first examined the effects of nanoparticles/materials on lung inflammation induced by bacterial endotoxin (lipopolysaccharide) as a test model against innate immunity, and demonstrated that nanoparticles instilled through both an intratracheal tube and an inhalation system can exacerbate lung inflammation. Secondly, we examined the effects of nanoparticles/materials on allergic pathophysiology, and showed that repetitive pulmonary exposure to nanoparticles has aggravating effects on allergic airway inflammation, including adjuvant effects on Th2-milieu. Taken together, nanoparticle exposure may synergistically facilitate pathological inflammatory conditions in the lung via both innate and adaptive immunological abnormalities.


Nanoparticles Nanomaterials Lung inflammation Sensitivity Asthma 

Copyright information

© The Japanese Society for Hygiene 2010

Authors and Affiliations

  1. 1.Department of Public Health and Molecular Toxicology, School of PharmacyKitasato UniversityTokyoJapan

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