Cellular and Molecular Bioengineering

, Volume 4, Issue 4, pp 579–590

Bone Physiology, Biomaterial and the Effect of Mechanical/Physical Microenvironment on Mesenchymal Stem Cell Osteogenesis

  • Xiaoling Liao
  • Shaoying Lu
  • Yue Zhuo
  • Christina Winter
  • Wenfeng Xu
  • Bo Li
  • Yingxiao Wang
Article

Abstract

In this review, we summarize the research progress in understanding the physiology of bone cells interacting with different mechanical/physical environments during bone tissue regeneration/repair. We first introduce the cellular composition of the bone tissue and the mechanism of the physiological bone regeneration/repair process. We then describe the properties and development of biomaterials for bone tissue engineering, followed by the highlighting of research progresses on the cellular response to mechanical environmental cues. Finally, several latest advancements in bone tissue regeneration and remaining challenges in the field are discussed for future research directions.

Keywords

Mechanical environment Bone repair Tissue engineering Scaffolds Bone cells 

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Copyright information

© Biomedical Engineering Society 2011

Authors and Affiliations

  • Xiaoling Liao
    • 1
    • 2
  • Shaoying Lu
    • 2
  • Yue Zhuo
    • 2
  • Christina Winter
    • 2
  • Wenfeng Xu
    • 1
  • Bo Li
    • 1
  • Yingxiao Wang
    • 2
    • 3
  1. 1.Biomaterials and Live Cell Imaging Institute, School of Metallurgy and Materials EngineeringChongqing University of Science and TechnologyChongqingPeople’s Republic of China
  2. 2.Department of Bioengineering and the Beckman Institute for Advanced Science and TechnologyUniversity of IllinoisUrbana-ChampaignUSA
  3. 3.Center for Biophysics and Computational Biology, Department of Integrative and Molecular PhysiologyInstitute for Genomic Biology, University of IllinoisUrbanaUSA

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