Radiological Physics and Technology

, Volume 12, Issue 4, pp 388–392 | Cite as

Usefulness of the frontal lobe bottom and cerebellum tuber vermis line as an alternative clue to set the axial angle parallel to the AC–PC line in I-123 IMP SPECT imaging: a retrospective study

  • Yasuhiro InokuchiEmail author
  • Saki Koya
  • Masahiro Uematsu
  • Tsuneyuki Takashina


We aimed to investigate whether the frontal lobe bottom and cerebellum tuber vermis (FLB–CTV) line on brain perfusion scintigraphy, using iodine-123 isopropyl iodoamphetamine single photon emission computed tomography (I-123 IMP SPECT) images, is useful to determine an axial angle parallel to the anterior commissure-posterior commissure (AC–PC) line. We measured the angular differences between the AC–PC line and the FLB–CTV line on midsagittal brain magnetic resonance imaging (MRI) scans of 100 patients. We also evaluated the angular differences of the FLB–CTV line between the IMP SPECT images and the computed tomography for attenuation correction (CTAC) images in the same 100 patients, using a reference line on the CTAC images. Furthermore, the inter-reader reproducibility of the FLB–CTV line measurements on IMP SPECT images of 50 patients between two readers was evaluated using the intra-class correlation coefficient (ICC) and 95% confidence interval (CI). The mean and standard deviation of the angular differences between the AC–PC and FLB–CTV lines on midsagittal brain MRI scans were − 1.24° and 1.14°, respectively. The mean and the standard deviation of the angular differences of the FLB–CTV line in the IMP SPECT and CTAC images were 0.87° and 0.48°, respectively. The ICC of the FLB–CTV line measurements on IMP SPECT images was 0.99 (95% CI 0.98–0.99). We demonstrated that the FLB–CTV line was almost parallel to the AC–PC line and could be reconstructed using IMP SPECT images. The FLB–CTV line can be used as additional evidence to set the axial angle parallel to the AC–PC line.


Brain SPECT imaging AC–PC line Anatomy 



The research in this study did not receive any specific aid from funding agencies in the form of grants, equipment, drugs, or any combination of these.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Research involving human participants

All procedures performed in these studies involving human participants were in accordance with the ethical standards as defined by the Institutional Review Board and the 1964 Helsinki Declaration and its later amendments, or comparable ethical standards.

Informed consent

Formal informed consent was not required at our institution to conduct this kind of study.


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Copyright information

© Japanese Society of Radiological Technology and Japan Society of Medical Physics 2019

Authors and Affiliations

  • Yasuhiro Inokuchi
    • 1
    Email author
  • Saki Koya
    • 1
  • Masahiro Uematsu
    • 1
  • Tsuneyuki Takashina
    • 1
  1. 1.Department of RadiologyEdogawa HospitalEdogawakuJapan

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