Early-age Ndufs4 knockout mice are an inappropriate animal model of Leigh syndrome
Letter to the Editor
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KeywordsMetabolic myopathy Brain Leigh syndrome Animal model Mice Knockout Complex-I Respiratory chain
Compliance with ethical standards
Conflict of interest
There are no conflicts of interest.
International ethical standards were met.
- 1.Saito S, Takahashi Y, Ohki A, Shintani Y, Higuchi T. Early detection of elevated lactate levels in a mitochondrial disease model using chemical exchange saturation transfer (CEST) and magnetic resonance spectroscopy (MRS) at 7 T-MRI. Radiol Phys Technol. 2018. https://doi.org/10.1007/s12194-018-0490-1.Google Scholar
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