Myocardial motion analysis based on an optical flow method using tagged MR images
We developed a method of velocimetry based on an optical flow method using quantitative analyses of tagged magnetic resonance (MR) images (tagged MR-optical flow velocimetry, tMR-O velocimetry). The purpose of our study was to examine the accuracy of measurement of the proposed tMR-O velocimetry. We performed retrospective pseudo-electrocardiogram (ECG) gating tagged cine MR imaging on a rotating phantom. We optimized imaging parameters for tagged MR imaging, and validated the accuracy of tMR-O velocimetry. Our results indicated that the difference between the reference velocities and the computed velocities measured using optimal imaging parameters was less than 1%. In addition, we performed tMR-O velocimetry and echocardiography on 10 healthy volunteers, for four sections of the heart (apical, midventricular, and basal sections aligned with the short-axis, and a four-chamber section aligned with the long-axis), and obtained radial and longitudinal myocardial velocities in these sections. We compared the myocardial velocities obtained using tMR-O velocimetry with those obtained using echocardiography. Our results showed good agreement between tMR-O velocimetry and echocardiography in the radial myocardial velocities in three short-axial sections and longitudinal myocardial velocities on the midventricular portion of the four-chamber section in the long-axis. In the study conducted on the rotating phantom, tMR-O velocimetry showed high accuracy; moreover, in the healthy volunteers, the myocardial velocities obtained using tMR-O velocimetry were relatively similar to those obtained using echocardiography. In conclusion, tMR-O velocimetry is a potentially feasible method for analyzing myocardial motion in the human heart.
KeywordsMyocardium Myocardial motion Tagged MR imaging Optical flow Echocardiography
This study was supported by Regional Innovation R&D Program Grant from Japanese Ministry of Economy, Trade and Industry (grant number, 21U3044A).
This study was funded by Regional Innovation R&D Program Grant from Japanese Ministry of Economy, Trade and Industry in 2009, 2010 (Grant number, 21U3044A).
Compliance with ethical standards
Conflict of interest
Takashi Kosugi and Haruo Isoda have received a Regional Innovation R&D Program grant from Japanese Ministry of Economy, Trade and Industry in 2009, 2010 (grant number, 21U3044A). Takafumi Kosugi is an employee of Renaissance of Technology Corporation. Takashi Kosugi is a stock holder and the president of Renaissance of Technology Corporation. Yoshiaki Komori is an employee of Siemens Healthcare K.K. The remaining authors have no conflict of interest.
Our research project has been approved by our institutional review board (IRB). All procedures performed in studies involving human participants were in accordance with the ethical standards of the IRB and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study. This article does not contain any studies conducted on animals.
- 1.Vital Statistics 2011 of Japan. http://www.mhlw.go.jp/english/database/db-hw/populate/dl/03.pdf. Accessed July 22, 2017.
- 5.Sandstede JJ, Johnson T, Harre K, Beer M, Hofmann S, Pabst T, Kenn W, Voelker W, Neubauer S, Hahn D. Cardiac systolic rotation and contraction before and after valve replacement for aortic stenosis: a myocardial tagging study using MR imaging. AJR Am J Roentgenol. 2002;178:953–8. https://doi.org/10.2214/ajr.178.4.1780953.CrossRefPubMedGoogle Scholar
- 10.Smal I, Carranza-Herrezuelo N, Klein S, Wielopolski P, Moelker A, Springeling T, Bernsen M, Niessen W, Meijering E. Reversible jump MCMC methods for fully automatic motion analysis in tagged MRI. Med Image Anal. 2012;16:301–24. https://doi.org/10.1016/j.media.2011.08.006.CrossRefPubMedGoogle Scholar
- 19.Petersen SE, Jung BA, Wiesmann F, Selvanayagam JB, Francis JM, Hennig J, Neubauer S, Robson MD. Myocardial tissue phase mapping with cine phase-contrast MR imaging: regional wall motion analysis in healthy volunteers. Radiology. 2006;238:816–26. https://doi.org/10.1148/radiol.2383041992.CrossRefPubMedGoogle Scholar
- 21.Amundsen BH, Crosby J, Steen PA, Torp H, Slørdahl SA, Støylen A. Regional myocardial long-axis strain and strain rate measured by different tissue Doppler and speckle tracking echocardiography methods: a comparison with tagged magnetic resonance imaging. Eur J Echocardiogr. 2009;10:229–37. https://doi.org/10.1093/ejechocard/jen201.PubMedCrossRefGoogle Scholar