Customization of normal data base specific for 3-tesla MRI is mandatory in VSRAD analysis
- 118 Downloads
A voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD) was used for quantitative analysis of parahippocampal atropy with 1.5-tesla (T) MRI in a voxel-wise manner. The analysis of images acquired under a different imaging condition provides an error factor that has a calculated value. Clinical application of 3T-MRI is necessary for establishing a normal data base (N-DB) specific for 3T-MRI data, which permits appropriate application of VSRAD. We established an N-DB specific for 3T-MRI for use in VSRAD. The “Z-score of the parahippocampal gyrus” was 0.79 ± 0.32, and the N-DB of each age group did not have a big deflection when we analyzed a group of physically unimpaired persons in an N-DB specific for 3T-MRI. Therefore, we were able to confirm the validity of the customized N-DB. The “Z-score of the parahippocampal gyrus” was 1.62 ± 0.47 for the N-DB of VSRAD. The numerical value was high for the group of physically unimpaired persons.
KeywordsHippocampus Central nervous system Magnetic resonance imaging (MRI) Voxel-based morphometry (VBM) Alzheimer’s disease Voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD)
- 17.Nunnemann S, Wohlschlager AM, Ilg R, Gaser C, Etgen T, Conrad B, et al. Accelerated aging of the putamen in men but not in women. Neurobiol Aging. Jul 2, 2007.Google Scholar