l-Thyroxine induces thermotolerance in yeast
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The cellular stress response (CSR) is a universal inducible reaction modulated, among others, by heat, drugs, and hormones. We aimed to investigate the role of l-thyroxine (T4) on the heat shock (HS) response in Saccharomyces cerevisiae. The CSR was evaluated by determining growth and viability of post-logarithmic phase grown yeast cultures after HS at 53 °C for 30 min. We found that long-term T4 exposure can induce a dose-dependent and Hsp90 and H+ trafficking-related thermotolerance in yeast.
KeywordsHeat shock response Thyroxine Heat shock proteins Yeast Thermotolerance
This study was funded by the Grant No. 5900 of the National and Kapodistrian University of Athens Research Account, Greece.
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Conflict of interest
The authors declare that they have no conflict of interest.
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