l-Thyroxine induces thermotolerance in yeast

  • Konstantinos PapamichaelEmail author
  • Basil Delitheos
  • Iordanis Mourouzis
  • Constantinos Pantos
  • Ekaterini Tiligada
Short Communication


The cellular stress response (CSR) is a universal inducible reaction modulated, among others, by heat, drugs, and hormones. We aimed to investigate the role of l-thyroxine (T4) on the heat shock (HS) response in Saccharomyces cerevisiae. The CSR was evaluated by determining growth and viability of post-logarithmic phase grown yeast cultures after HS at 53 °C for 30 min. We found that long-term T4 exposure can induce a dose-dependent and Hsp90 and H+ trafficking-related thermotolerance in yeast.


Heat shock response Thyroxine Heat shock proteins Yeast Thermotolerance 



This study was funded by the Grant No. 5900 of the National and Kapodistrian University of Athens Research Account, Greece.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Cell Stress Society International 2019

Authors and Affiliations

  • Konstantinos Papamichael
    • 1
    • 2
    Email author
  • Basil Delitheos
    • 1
  • Iordanis Mourouzis
    • 1
  • Constantinos Pantos
    • 1
  • Ekaterini Tiligada
    • 1
  1. 1.Department of Pharmacology, Medical SchoolNational and Kapodistrian University of AthensAthensGreece
  2. 2.Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUSA

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