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Cell Stress and Chaperones

, Volume 23, Issue 6, pp 1337–1343 | Cite as

Ions released from a S-PRG filler induces oxidative stress in Candida albicans inhibiting its growth and pathogenicity

  • Muneaki TamuraEmail author
  • Marni E. Cueno
  • Kazumasa Abe
  • Noriaki Kamio
  • Kuniyasu Ochiai
  • Kenichi Imai
Short Communication

Abstract

Candida albicans causes opportunistic fungal infections usually hidden among more dominant bacteria and does not exhibit high pathogenicity in vivo. Among the elderly, due to reduced host resistance to pathogens attributable to immunoscenesence, oral candidiasis is more likely to develop often leading to systemic candidiasis. Surface pre-reacted glass ionomer filler (S-PRG filler) is an ion-releasing functional bioactive glass that can release and recharge six ions which in turn strengthens tooth structure, inhibits demineralization arising from dental caries, and suppresses dental plaque accumulation. However, its effects on C. albicans have never been elucidated. Here, we evaluated the effects of ion released from S-PRG filler on C. albicans. Results show that extraction liquids containing released ions (ELIS) decreased the amount of hydrogen peroxide and catalase activity in C. albicans. Moreover, ELIS presence was found to affect C. albicans: (1) suppression of fungal growth and biofilm formation, (2) prevent adherence to denture base resin, (3) inhibit dimorphism conversion, and (4) hinder the capability to produce secreted aspartyl proteinase. Taken together, our findings suggest that ELIS induces oxidative stress in C. albicans and suppresses its growth and pathogenicity. In this regard, we propose that ELIS has the potential to be clinically used to help prevent the onset and inhibition of oral candidiasis among the elderly population.

Keywords

Candida albicans Oxidative stress S-PRG filler Pathogenicity 

Notes

Acknowledgements

We thank to Dr. Toshiyuki Nakatsuka (Shofu Inc.) for providing the S-PRG filler. This research was supported in part by funding from the Satoh Research Fund, a grant from the Dental Research Center of Nihon University School of Dentistry, KAKENHI (Japan Society for the Promotion of Science, C: 24593168 and 15K11456, Japan).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Cell Stress Society International 2018

Authors and Affiliations

  • Muneaki Tamura
    • 1
    Email author
  • Marni E. Cueno
    • 1
  • Kazumasa Abe
    • 2
  • Noriaki Kamio
    • 1
  • Kuniyasu Ochiai
    • 1
  • Kenichi Imai
    • 1
  1. 1.Department of MicrobiologyNihon University School of DentistryTokyoJapan
  2. 2.Nihon University School of Dentistry at MatsudoChibaJapan

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