Cell Stress and Chaperones

, Volume 22, Issue 4, pp 481–492 | Cite as

Small heat shock proteins in ageing and age-related diseases

  • Nikolaos Charmpilas
  • Emmanouil Kyriakakis
  • Nektarios Tavernarakis
SMALL HEAT SHOCK PROTEINS Mini Review
First Online:
Received:
Revised:
Accepted:

Abstract

Small heat shock proteins (sHSPs) are gatekeepers of cellular homeostasis across species, preserving proteome integrity under stressful conditions. Nonetheless, recent evidence suggests that sHSPs are more than molecular chaperones with merely auxiliary role. In contrast, sHSPs have emerged as central lifespan determinants, and their malfunction has been associated with the manifestation of neurological disorders, cardiovascular disease and cancer malignancies. In this review, we focus on the role of sHSPs in ageing and age-associated diseases and highlight the most prominent paradigms, where impairment of sHSP function has been implicated in human pathology.

Keywords

Small heat shock proteins Proteome Ageing Neurodegeneration Cardiovascular disease Immunity Cancer 
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Notes

Acknowledgements

We apologize to those colleagues whose work could not be referenced directly owing to space limitations. Work in the authors’ laboratory is funded by grants from the European Research Council (ERC), the European Commission Framework Programmes, and the Greek Ministry of Education. E.K. is supported by Stiftung für Herz- und Kreislaufkrankheiten.

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Copyright information

© Cell Stress Society International 2017

Authors and Affiliations

  1. 1.Institute of Molecular Biology and BiotechnologyFoundation for Research and Technology-HellasHeraklionGreece
  2. 2.Department of BiologyUniversity of CreteHeraklionGreece
  3. 3.Department of Biomedicine, Laboratory for Signal TransductionBasel University Hospital and University of BaselBaselSwitzerland
  4. 4.Department of Basic Sciences, Faculty of MedicineUniversity of CreteHeraklionGreece

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