Cell Stress and Chaperones

, Volume 20, Issue 2, pp 203–206 | Cite as

The transition from a rural to an urban environment alters expression of the human Ebola virus receptor Neiman-Pick C1: implications for the current epidemic in West Africa

Perspective and Reflection Article

References

  1. Bickler SW (2000) Non-communicable diseases: is their emergence in industrialized societies related to changes in neuroendocrine function? Med Hypotheses 54:825–858CrossRefPubMedGoogle Scholar
  2. Bickler SW (2006) Tropical enteropathy protects against Western diseases in environments of poor sanitation. Med Hypotheses 67:146–150CrossRefPubMedGoogle Scholar
  3. Bickler SW, De Maio A (2008) Western diseases: current concepts and implications for pediatric surgery research and practice. Pediatr Surg Int 24:251–255CrossRefPubMedGoogle Scholar
  4. Bowen ETW, Lloyd G, Harris WJ, Platt GS, Baskerville A, Vella EE (1977) Viral haemorrhagic fever in Southern Sudan and Northern Zaire. Lancet 1:571–573CrossRefPubMedGoogle Scholar
  5. Carette JE, Raaben M, Wong AC et al (2011) Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature 477:340–343CrossRefPubMedCentralPubMedGoogle Scholar
  6. Chan M (2014) “WHO Director-General addresses UN security council on Ebola.” World Health Organization, September 18, 2014. http://www.who.int/dg/speeches/2014/security-council-ebola/en/. Accessed 28 Oct 2014
  7. Chowell G, Nishiura H (2014) Transmission dynamics and control of Ebola virus disease (EVD): a review. BMC Med 12:196CrossRefPubMedCentralPubMedGoogle Scholar
  8. Coté M, Misasi J, Ren T et al (2011) Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection. Nature 477:344–348CrossRefPubMedCentralPubMedGoogle Scholar
  9. Fedson DS (2014) How will physicians respond to the next influenza pandemic? Clin Infect Dis 58:233–237CrossRefPubMedGoogle Scholar
  10. Frey T, De Maio A (2007) Increased expression of CD14 in macrophages after inhibition of the cholesterol biosynthetic pathway by lovastatin. Mol Med 13:592–604CrossRefPubMedCentralPubMedGoogle Scholar
  11. Frey T, De Maio A (2009) The antifungal agent itraconazole induces the accumulation of high mannos glycoproteins in macrophages. J Biol Chem 284:16882–16890CrossRefPubMedCentralPubMedGoogle Scholar
  12. Idaghdour Y, Storey JD, Jadallah SJ, Gibson G (2008) A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan Amazighs. PLoS Genet 4:e1000052CrossRefPubMedCentralPubMedGoogle Scholar
  13. Johnson KM, Webb PA, Lange JV, Murphy FA (1977) A new virus causing acute haemorrhagic fever in Zaire. Lancet 1:569–571CrossRefPubMedGoogle Scholar
  14. Kohjima M, Enjoji M, Yoshimoto T et al (2013) Add-on therapy of pitavastatin and eicosapentaenoic acid improves outcome of peginterferon plus ribavirin treatment for chronic hepatitis C. J Med Virol 85:250–260CrossRefPubMedGoogle Scholar
  15. Krishnan A, Miller EH, Herbert AS et al (2012) Niemann-Pick C1 (NPC1)/NPC1-like1 chimeras define sequences critical for NPC1’s function as a filovirus entry receptor. Viruses 4:2471–2484CrossRefPubMedCentralPubMedGoogle Scholar
  16. Mañes S, del Real G, Martinez AC (2003) Pathogens: raft hijackers. Nat Rev 3:557–568Google Scholar
  17. Martines RB, Ng DL, Greer PW, Rollin PE, Zaki SR (2014) Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses. J Pathol. doi:10.1002/path.4456 Google Scholar
  18. Miller EH, Chandran K (2012) Filovirus entry into cells—new insights. Curr Opin Virol 2:206–214CrossRefPubMedGoogle Scholar
  19. Nath AP, Arafat D, Gibson G (2012) Using blood informative transcripts in geographical genomics: impact of lifestyle on gene expression in Fijians. Front Genet 3:243CrossRefPubMedCentralPubMedGoogle Scholar
  20. Ng M, Ndungo E, Jangra RK et al (2014) Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1. Virology 468-470C:637–646CrossRefGoogle Scholar
  21. Niño DF, Cauvi DM, De Maio A (2014) Itraconazole, a commonly used antifungal, inhibits Fcγ receptor-mediated phagocystosis: alteration of Fcγ receptor glycosylation and gene expression. Shock 42:52–59CrossRefPubMedGoogle Scholar
  22. Rosenbaum AI, Maxfield FR (2011) Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches. J Neurochem 116:789–795CrossRefPubMedCentralPubMedGoogle Scholar
  23. Shoemaker CJ, Chornberg KL, Delos SE et al (2013) Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection. PLoS One 8:e56265CrossRefPubMedCentralPubMedGoogle Scholar
  24. Vasunilashorn S, Crimmins EM, Kim JKI et al (2010) Blood lipids, infection, and inflammatory markers in the Tsimane of Bolivia. Am J Hum Biol 22:731–740CrossRefPubMedCentralPubMedGoogle Scholar
  25. WHO (2014a) October 25 Ebola Response Roadmap. World Health Organization. http://apps.who.int/iris/bitstream/10665/137185/1/roadmapupdate25Oct14_eng.pdf?ua=1. Accessed October 28, 2014
  26. WHO (2014b) Ebola Response Roadmap. World Health Organization. http://apps.who.int/iris/bitstream/10665/131596/1/EbolaResponseRoadmap.pdf?ua=1&ua=1. Accessed October 28, 2014
  27. WHO Ebola Response Team (2014) Ebola virus disease in West Africa—first 9 months of the epidemic and forward projections. N Engl J Med 371:1481–1495CrossRefGoogle Scholar

Copyright information

© Cell Stress Society International 2014

Authors and Affiliations

  1. 1.Center for Investigations of Health and Education DisparitiesUniversity of California San DiegoLa JollaUSA
  2. 2.Department of Surgery, School of MedicineUniversity of CaliforniaLa JollaUSA
  3. 3.Department of Neurosciences, School of MedicineUniversity of CaliforniaLa JollaUSA
  4. 4.Department of SurgeryNaval Medical Center San DiegoSan DiegoUSA
  5. 5.Division of Pediatric SurgeryRady Children’s HospitalSan DiegoUSA

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