Cell Stress and Chaperones

, Volume 13, Issue 1, pp 1–10 | Cite as

The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells

  • Mathias Gehrmann
  • Jürgen Radons
  • Michael Molls
  • Gabriele Multhoff
Mini Review
First Online:
Received:
Revised:
Accepted:

Abstract

Evidence that membrane-bound and extracellular heat shock proteins (HSPs) with molecular weights of 70 and 90 kDa are potent stimulators of the immune responses has accumulated over the last decade. In this review, we discuss the modulation of Hsp70 expression, a major stress-inducible member of the HSP70 family, in the cytoplasm and on the plasma membrane of tumor cells by clinically applied interventions such as radio- and chemotherapy.

Keywords

Hsp70 Membrane expression Stress response modifiers NK cell Tumor 

Abbreviations

13-RA

13-cis-retinoic acid

ALL

acute lymphoid leukemia

AML

acute myeloid leukemia

APC(s)

antigen presenting cell(s)

APL

acute promyelocytic leukemia

ARA-CTP

arabinosyl-cytosin-triphosphate

ASA

acetyl-salicylic acid

ATRA

all-trans-retinoic acid

B-CLL

B cell chronic lymphoid leukemia

CD

cluster of differentiation (nomenclature for surface proteins of human leucocytes)

CLX

celecoxib

COX

cyclooxygenase

ER

endoplasmic reticulum

Hsp

heat shock protein

IL

interleukin

NCR

natural cytotoxicity receptor

NHL

non-Hodgkin lymphoma

NK

natural killer cell

NKG2D

C-type lectin-like immunoreceptor on NK cells

NKT cells

natural killer-like T cells

PI3K

phosphatidyl-inositol-3-phosphat kinase

PIO

pioglitazone

PIPLC

phosphatidyl-inositol-specific phospholipase C

PKC

protein kinase C

RFX

rofecoxib

SBU

sodium butyrate

TKD

14-mer Hsp70 peptide with the amino acid sequence T-K-D-N-N-L-L-G-R-F-E-L-S-G

TLR

Toll-like receptor

TNF

tumor necrosis factor

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Notes

Acknowledgment

This work was supported in part by the EU-Transnet project MRTN-2004-512253, the DFG project MU1238 7/2, and the multimmune GmbH, Munich. We want to thank Prof. Graham Pockley (University of Sheffield, UK, presently Technical University Munich) for constructive suggestions and for proofreading of the manuscript.

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Copyright information

© Cell Stress Society International 2008

Authors and Affiliations

  • Mathias Gehrmann
    • 1
  • Jürgen Radons
    • 2
  • Michael Molls
    • 1
  • Gabriele Multhoff
    • 1
  1. 1.Department of Radiotherapy and Radiooncology and Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)–Institute of Pathology, Clinical Cooperation Group “Innate Immunity in Tumor Biology”University Hospital rechts der Isar, Technische Universität MünchenMunichGermany
  2. 2.Institute of Medical Biochemistry and Molecular BiologyUniversity of Greifswald, Clinical CenterGreifswaldGermany

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