Clinical significance of autologous blood transfusions in bone marrow harvest from unrelated donors

International Journal of Hematology volume 111, pages833–839(2020)Cite this article

Abstract

In the Japan Marrow Donor Program (JMDP), autologous blood is collected from most unrelated bone marrow (BM) donors. We retrospectively evaluated 5772 donors who underwent BM harvest between 2010 and 2015 through the JMDP. Autologous blood was collected in 96.8% of the donors; the wastage rate was 0.6%. Allogeneic blood transfusion was not required. The mean hemoglobin (Hb) levels were 12.1 g/dL after the BM harvest (mean 891 mL) together with autologous blood transfusion (mean 596 mL). Propensity-score matching was used to adjust the backgrounds. Among donors with harvested BM of 100–400 mL, autologous blood transfusion had no impact on Hb levels or complications after BM harvest. Among donors with harvested BM of > 400 mL, more autologous blood transfusion followed by a bleeding volume of ≤ 100 mL did not confer clinical benefit to donors compared with less autologous blood transfusion followed by a bleeding volume of > 300 mL. The findings of the present study suggest that autologous blood transfusion to BM donors is excessive in terms of Hb changes and post-harvest outcomes.

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Acknowledgements

The authors thank all physicians at the collection centers who contributed valuable data on BM harvest to the JMDP. The authors also thank all the members of the data management committees of JMDP for their assistance.

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Affiliations

  1. Division of Hematology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotuke, Tochigi, 329-0498, Japan

    Shin-ichiro Fujiwara

  2. Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University, Fukushima, Japan

    Kazuhiko Ikeda

  3. Japanese Red Cross Hokkaido Block Blood Center, Sapporo, Japan

    Shuichi Kino

  4. Transfusion Medicine, Hachioji Medical Center of Tokyo Medical University, Tokyo, Japan

    Asashi Tanaka

  5. Department of Transfusion Medicine, University of Tsukuba Hospital, Tsukuba, Japan

    Yuichi Hasegawa

  6. Department of Transfusion Medicine, Osaka City University Hospital, Osaka, Japan

    Keizo Fujino

  7. Department of Transfusion Medicine, Toranomon Hospital, Tokyo, Japan

    Shigeyoshi Makino

  8. Department of Nursing, Shinko Hospital, Kobe, Japan

    Mayumi Matsumoto

  9. Division of Blood Transfusion Service, Gunma University Hospital, Maebashi, Japan

    Akihiko Yokohama

  10. Department of Transfusion and Cell Therapy, Hamamatsu University School of Medicine, Hamamatsu, Japan

    Akihiro Takeshita

  11. Division of Cell Transplantation and Transfusion, Jichi Medical University Hospital, Shimotsuke, Japan

    Kazuo Muroi

Authors
  1. Shin-ichiro Fujiwara
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  2. Kazuhiko Ikeda
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  3. Shuichi Kino
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  4. Asashi Tanaka
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  5. Yuichi Hasegawa
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  6. Keizo Fujino
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  7. Shigeyoshi Makino
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  8. Mayumi Matsumoto
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  9. Akihiko Yokohama
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  10. Akihiro Takeshita
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  11. Kazuo Muroi
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Contributions

All authors contributed to the study conception and design. Data analysis were performed by S.F. The first draft of the manuscript was written by SF and KM and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Shin-ichiro Fujiwara.

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The authors report no potential competing interests.

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Cite this article

Fujiwara, Si., Ikeda, K., Kino, S. et al. Clinical significance of autologous blood transfusions in bone marrow harvest from unrelated donors. Int J Hematol 111, 833–839 (2020). https://doi.org/10.1007/s12185-020-02851-8

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Keywords

  • Autologous blood transfusion
  • Bone marrow harvest
  • Unrelated donor