JSH practical guidelines for hematological malignancies, 2018: II. Lymphoma-10. Hodgkin lymphoma (HL)

  • Hirokazu NagaiEmail author


Hodgkin lymphoma (HL) accounts for approximately 30% of all malignant lymphomas in Western countries, and approximately 5–10% in Japan.

It has a bimodal incidence pattern across age groups with one peak in young adults (20s) and the other in middle-aged adults (50–60 years old).

Many patients are initially asymptomatic or have painless superficial lymphadenopathy. Approximately 75% of cases are detected from cervical and supraclavicular lymphadenopathy. A mediastinal mass is detected in approximately 60% of patients with nodular sclerosis HL.

Hematologic findings include leukocytosis, lymphopenia, eosinophilia, anemia, elevated alkaline phosphatase, elevated erythrocyte sedimentation rate, elevated CRP, and reduced cell-mediated immunity.

Histopathologically, HL is a lymphoma characterized by proliferation of tumor cells such as Hodgkin/Reed–Sternberg (HRS) cells and lymphocyte predominant (LP) cells (“popcorn” cells). In 2017 WHO Classification, HL is classified into two...


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© Japanese Society of Hematology 2019

Authors and Affiliations

  1. 1.Clinical Research CenterNational Hospital Organization Nagoya Medical CenterNagoyaJapan

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